(5E)-5-[[3-methoxy-4-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (5E)-5-[[3-methoxy-4-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C₂₆H₂₉NO₃S
• 分子量: 435.6
• InChiKey: UOGQETBKPACOLX-LPYMAVHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted heterocycles for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20060004059A1

  公开（公告）日：2006-01-05

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及公式（I）的某些取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病中有用，例如2型糖尿病，脂肪细胞分化，不受控制的增殖（如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或癌症总体）和炎症（如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病）。
• BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：EP1214304A1

  公开（公告）日：2002-06-19
• BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：EP1214305A1

  公开（公告）日：2002-06-19
• US6515003B1
  申请人：——

  公开号：US6515003B1

  公开（公告）日：2003-02-04
• US7226940B2
  申请人：——

  公开号：US7226940B2

  公开（公告）日：2007-06-05