2-[4-(3-Fluoro-4-propoxyphenyl)spiro[chromene-2,4'-piperidine]-1'-yl]acetic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 2-[4-(3-Fluoro-4-propoxyphenyl)spiro[chromene-2,4'-piperidine]-1'-yl]acetic acid
• 化学式: C₂₄H₂₆FNO₄
• 分子量: 411.5
• InChiKey: GBHPJQNPWRTMGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
  申请人：nLife Therapeutics, S.L.

  公开号：US10071163B2

  公开（公告）日：2018-09-11

  The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a neurotransmitter transporter. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes.

  本发明提供了一种共轭物，该共轭物包含(i)与靶核酸序列互补的核酸，该核酸的表达可防止或减少靶核酸的表达；(ii)能够与神经递质转运体高亲和力结合的选择剂。本发明的共轭物可用于将核酸递送至相关细胞，从而治疗需要下调靶核酸编码蛋白的疾病，也可用于将成像剂递送至细胞以进行诊断。
• Glycine reuptake inhibitors for treating drug and alcohol dependence
  申请人：MSD Oss B.V.

  公开号：EP1841418B1

  公开（公告）日：2013-04-17
• COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES
  申请人：Nlife Therapeutics S.L.

  公开号：EP2560687B1

  公开（公告）日：2017-05-24
• Glycine Reuptake Inhibitors for Treatment of Drug Dependence
  申请人：Molander Anna

  公开号：US20080051456A1

  公开（公告）日：2008-02-28

  The invention relates to a method of treatment or prevention of drug addiction, in particular alcoholism, in humans, comprising administering to a subject, in need thereof, an effective amount of a Gly-T1 inhibitor, in particular N-methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl glycine or a pharmaceutically acceptable salt thereof.
• US9193969B2
  申请人：——

  公开号：US9193969B2

  公开（公告）日：2015-11-24