(5E)-5-[[3-chloro-4-[5,5,8,8-tetramethyl-3-(trifluoromethyl)-6,7-dihydronaphthalen-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (5E)-5-[[3-chloro-4-[5,5,8,8-tetramethyl-3-(trifluoromethyl)-6,7-dihydronaphthalen-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C₂₅H₂₃ClF₃NO₂S
• 分子量: 494.0
• InChiKey: SUDPKDWSGHSBDG-KEBDBYFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：EP1214305A1

  公开（公告）日：2002-06-19
• [EN] BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION<br/>[FR] BENZYLIDENE-THIAZOLIDINEDIONES ET ANALOGUES ET LEUR UTILISATION POUR LE TRAITEMENT DE L'INFLAMMATION
  申请人：MAXIA PHARMACEUTICALS INC

  公开号：WO2001016123A1

  公开（公告）日：2001-03-08

  The present invention relates to certain substituted heterocycles of Formula (I) which may be useful in the treatment of diseases related to uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.