TH-9402 hydrobromide | 333957-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: TH-9402 hydrobromide
• 英文别名: methyl 2-(3-amino-4,5-dibromo-6-iminoxanthen-9-yl)benzoate;hydrobromide
• CAS: 333957-97-4
• 化学式: C21H15Br3N2O3
• 分子量: 583.1
• InChiKey: KTCUAOHNCDXNFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Rhodamine derivatives for photodynamic diagnosis and treatment
  申请人：Roy Denis-Claude

  公开号：US20060088507A1

  公开（公告）日：2006-04-27

  The present invention relates to the use of the photoactivable derivatives for the photodynamic treatment for the selective destruction and/or inactivation of immunologically reactive cells without affecting the normal cells and without causing systemic toxicity for the patient, wherein appropriate intracellular levels of said derivatives are achieved and irradiation of a suitable wavelength and intensity is applied.

  本发明涉及使用光活性衍生物进行光动力治疗，以选择性地破坏和/或灭活免疫反应细胞，而不影响正常细胞，也不会对患者造成全身毒性，其中所述衍生物可达到适当的细胞内水平，并采用适当波长和强度的照射。
• RHODAMINE DERIVATIVES FOR PHOTODYNAMIC DIAGNOSIS AND TREATMENT
  申请人：UNIVERSITE DE MONTREAL

  公开号：EP1267931B1

  公开（公告）日：2004-12-29
• IMMUNOLOGIC COMPOUNDS FOR PREVENTION, PROTECTION, PROPHYLAXIS OR TREATMENT OF IMMUNOLOGICAL DISORDERS, INFECTIONS AND CANCER
  申请人：UNIVERSITE DE MONTREAL

  公开号：EP1701740A1

  公开（公告）日：2006-09-20
• JP2011229537A
  申请人：——

  公开号：JP2011229537A

  公开（公告）日：2011-11-17
• Immunologic compounds for prevention, protection, prophylaxis or treatment of immunological disorders, infections and cancer
  申请人：Roy Claude Denis

  公开号：US20070098732A1

  公开（公告）日：2007-05-03

  The present invention relates to the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of vaccines for immunoprotection or immunomodulation. More particularly, the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of an immunologic compound for prevention, protection, prophylaxis or treatment of an immunological disorder, infection and/or a cancer in an individual, which comprises treatment of the individual cells or components thereof with a photoactivatable molecule selected from the group consisting of compounds I to XVIII, wherein the photoactivatable molecule is activated by a light of appropriate wavelength, thereby activating the photoactivatable molecule and causing prevention, protection, prophylaxis or treatment of the immunological disorder, infection and/or a cancer.