N-[2,2-diphenyl-5-(4-phenylpiperidin-1-yl)pentyl]naphthalene-1-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[2,2-diphenyl-5-(4-phenylpiperidin-1-yl)pentyl]naphthalene-1-sulfonamide
• 化学式: C₃₈H₄₀N₂O₂S
• 分子量: 588.8
• InChiKey: CXBVKXBTUMBDLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Amine compounds, their production and use
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0712845A1

  公开（公告）日：1996-05-22

  A compound of the formula: wherein Ar¹ and Ar² independently present an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydro-carbon group having at least 2 carbon atoms and optionally having ether oxygen or sulfur in the carbon chain; R¹ and R³ independently represent -CO-R, -CONH-R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R² and R⁴ independently represent hydrogen or an alkyl group; R² and R⁴ independently represent hydrogen or an alkyl group; R¹ and R² or R³ and R⁴, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof has excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.

  式中的化合物： 其中 Ar¹ 和 Ar² 独立地表示任选取代的芳香族基团；P 和 Q 独立地表示至少具有 2 个碳原子且碳链中任选具有醚氧或硫的二价脂族碳氢基团；R¹ 和 R³ 独立地表示-CO-R、-CONH-R（R 表示烃基或杂环基）或烃基；R² 和 R⁴ 独立地代表氢或烷基；R² 和 R⁴ 独立地代表氢或烷基；R¹ 和 R² 或 R³ 和 R⁴ 与相邻的氮原子一起可形成含氮杂环基团；以及 j 代表 0 或 1，或其盐具有优异的 GnRH 受体拮抗活性，可用作激素依赖性疾病和其他疾病的预防和治疗药物。
• MELANIN CONCENTRATING HORMONE ANTAGONISTS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1219294A1

  公开（公告）日：2002-07-03

  A compound represented by the formula wherein Ar1 and Ar2 are each an aromatic group optionally having substituents, P and Q are each a divalent aliphatic hydrocarbon group which optionally contains ether oxygen or ether sulfur in a carbon chain and which optionally has substituents, R1 and R3 are each (i) a hydrogen atom, (ii) an acyl group or (iii) an hydrocarbon group optionally having substituents, R2 and R4 are each (i) a hydrogen atom, (ii) an alkyl group optionally having substituents or (iii) an alkylcarbonyl optionally having substituents, R1 and R2 or R3 and R4 each optionally forms, together with the adjacent nitrogen atom, a monocyclic or fused nitrogen-containing heterocyclic group optionally having substituents, j is 0 or 1, a salt thereof or a prodrug thereof are useful as melanin-concentrating hormone antagonists.

  一种由式表示的化合物 其中 Ar1 和 Ar2 分别是可选具有取代基的芳香基团，P 和 Q 分别是可选在碳链中含有醚氧或醚硫且可选具有取代基的二价脂肪族烃基，R1 和 R3 分别是 (i) 氢原子，(ii) 丙烯酸基团或 (iii) 可选具有取代基的烃基，R2 和 R4 分别是 (i) 氢原子，(ii) 可选具有取代基的烷基或 (iii) 可选具有取代基的烷基羰基，R1 和 R2 或 R3 和 R4 各自可选具有取代基的芳香基团、(R1和R2或R3和R4各自与相邻的氮原子一起形成单环或融合的含氮杂环基团，该杂环基团可选择具有取代基，j为0或1，其盐或原药可用作黑色素浓缩激素拮抗剂。
• US5633248A
  申请人：——

  公开号：US5633248A

  公开（公告）日：1997-05-27