2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-[2-[(3S)-3-(phenylmethoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]ethylamino]ethyl]phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-[2-[(3S)-3-(phenylmethoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]ethylamino]ethyl]phenol
• 化学式: C₂₇H₃₁NO₆
• 分子量: 465.5
• InChiKey: KAHONMCTSMKOLY-ZCYQVOJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  100
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Medicinal arylethanolamine compounds
  申请人：Coe Mary Diane

  公开号：US20060205790A1

  公开（公告）日：2006-09-14

  The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

  本发明涉及化合物的新型公式(I)，以及其盐，溶剂合物和生理上可接受的衍生物，其制备方法，含有它们的药物组合物，以及它们在治疗中的应用，特别是在预防和治疗呼吸系统疾病方面的应用。
• MEDICINAL ARYLETHANOLAMINE COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1554264A2

  公开（公告）日：2005-07-20
• [EN] MEDICINAL COMPOUNDS<br/>[FR] COMPOSES MEDICINAUX
  申请人：GLAXO GROUP LTD

  公开号：WO2004037807A2

  公开（公告）日：2004-05-06

  The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
• [EN] MEDICINAL ARYLETHANOLAMINE COMPOUNDS<br/>[FR] COMPOSES MEDICINAUX
  申请人：GLAXO GROUP LTD

  公开号：WO2004037807A9

  公开（公告）日：2004-08-19

  [EN] The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
  [FR] Cette invention a trait à de nouveaux composés correspondant à la formule (I) ainsi qu'à des sels, des solvates et des dérivés, acceptables du point de vue physiologique, de ceux-ci. Elle concerne également un procédé permettant de les fabriquer, des compositions pharmaceutiques les contenant ainsi que l'usage qui en fait en matière de thérapie, notamment pour la prophylaxie et le traitement de maladies des voies respiratoires.