[4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenyl] (Z)-octadec-9-enoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: [4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenyl] (Z)-octadec-9-enoate
• 化学式: C₃₆H₅₂O₃
• 分子量: 532.8
• InChiKey: LWESQTUBSKJLSN-MCDLAGIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.2
• 重原子数：
  39
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight
  申请人：LABORATORIOS S.A.L.V.A.T., S.A.

  公开号：EP0771817A2

  公开（公告）日：1997-05-07

  The estrogen is selected from the group consisting of estrone, diethylstilbestrol, estriol, estradiol and ethinyl estradiol; the fatty acid is selected from the group consisting of oleic, linoleic, linolenic, stearic, palmitic, palmitoleic and arachidonic acids. They mimic the function of estrone monooleate, as a signal that informs the brain of the size of fat tissue mass. Preferred compositions for intravenous injection comprise the monoester incorporated in a lipidic suspension, prepared from lipoproteins or from liposome components such a soy oil and egg phospolipids. When administered to rats with a 15% of total adipose tissue, they produce weight reduction of about 10%, by a new and unexpected mechanism. They are useful for the treatment of obesity and/or overweight in mammals, with the advantages of high efficacy and low toxicity.

  雌激素选自雌酮、己烯雌酚、雌三醇、雌二醇和炔雌醇组成的组；脂肪酸选自油酸、亚油酸、亚麻酸、硬脂酸、棕榈酸、棕榈油酸和花生四烯酸组成的组。它们模仿单油酸雌酮的功能，作为一种信号，告知大脑脂肪组织的大小。用于静脉注射的优选组合物包括掺入脂质悬浮液中的单酯，该悬浮液由脂蛋白或脂质体成分（如大豆油和鸡蛋磷脂）制备而成。当给总脂肪组织含量为 15%的大鼠用药时，它们通过一种意想不到的新机制使体重减轻约 10%。它们具有高效、低毒的优点，可用于治疗哺乳动物的肥胖和/或超重。
• Methods of using fatty-acid esters of estrogens and thermogenic compounds for reducing the body weight of a mammal and compositions containing the same
  申请人：Alemany Maria

  公开号：US20060084637A1

  公开（公告）日：2006-04-20

  Compositions and methods for reducing the body weight of a mammal are disclosed. The invention is directed to methods for reducing the body weight in a mammal comprising administering therapeutically effective amounts of a fatty-acid ester of an estrogen or estrogen derivative and a fatty-acid, and a thermogenic compound. Furthermore the invention is directed to compositions comprising a fatty-acid ester of an estrogen or estrogen derivative and a fatty-acid, and a thermogenic compound.

  本发明公开了减轻哺乳动物体重的组合物和方法。本发明涉及减轻哺乳动物体重的方法，包括施用治疗有效量的雌激素或雌激素衍生物的脂肪酸酯和生热化合物。此外，本发明还涉及包含一种雌激素或雌激素衍生物的脂肪酸酯和一种脂肪酸以及一种致热化合物的组合物。
• Methods of using fatty-acid esters of estrogens and serotonin reuptake inhibiting compounds for reducing the body weight of a mammal and compositions containing the same
  申请人：Alemany Maria

  公开号：US20060084636A1

  公开（公告）日：2006-04-20

  Compositions and methods for reducing the body weight of a mammal are disclosed. The invention is directed to methods for reducing the body weight in a mammal comprising administering therapeutically effective amounts of a fatty-acid ester of an estrogen or estrogen derivative and a fatty-acid, and a serotonin reuptake-inhibiting compound. Furthermore the invention is directed to compositions comprising a fatty-acid ester of an estrogen or estrogen derivative and a fatty-acid, and a serotonin reuptake-inhibiting compound.

  本发明公开了减轻哺乳动物体重的组合物和方法。本发明涉及减轻哺乳动物体重的方法，包括施用治疗有效量的雌激素或雌激素衍生物的脂肪酸酯和5-羟色胺再摄取抑制化合物。此外，本发明还涉及由雌激素或雌激素衍生物的脂肪酸酯和脂肪酸以及血清素再摄取抑制化合物组成的组合物。
• Oleate monoesters of estrogens for the treatment of obesity and/or overweight
  申请人：Oleoyl-Estrone Developments, S.I.

  公开号：EP0771817B1

  公开（公告）日：2003-03-26
• METHODS OF USING FATTY-ACID ESTERS OF ESTROGENS AND SEROTONIN REUPTAKE INHIBITING COMPOUNDS FOR REDUCING THE BODY WEIGHT OF A MAMAL AND COMPOSITIONS CONTAINING THE SAME
  申请人：Oleoyl-Estrone Developments SL

  公开号：EP1807089A1

  公开（公告）日：2007-07-18