N-(6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-hydroxyacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-(6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-hydroxyacetamide
• 化学式: C₁₄H₁₆N₂O₄
• 分子量: 276.29
• InChiKey: IWTCFIIOUXJOOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY
  申请人：Wipf Peter

  公开号：US20110172214A1

  公开（公告）日：2011-07-14

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种有用于自由基清除的组合物和相关方法，特别是对线粒体的选择性。该化合物包括连接到线粒体靶向基团的亚硝基含有基团。该化合物可以交联成二聚体而不失去活性。本文还提供了一种方法，用于预防、缓解和治疗放射性损伤。该方法包括将上述所述的化合物以有效的剂量和用药方案输送给患者，以预防、缓解或治疗放射性损伤。
• USE OF TARGETED NITROXIDE AGENTS IN BONE HEALING
  申请人：Epperly Michael W.

  公开号：US20120252733A1

  公开（公告）日：2012-10-04

  Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.

  本文提供了一种促进骨愈合和生长的组合物及相关方法。这些化合物包含一个连接到线粒体靶向基团的亚硝基含有基团。这些化合物可以交联成二聚体而不失去活性。
• TARGETED NITROXIDE AGENTS
  申请人：Wipf Peter

  公开号：US20130102626A1

  公开（公告）日：2013-04-25

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一些用于自由基清除的组合物和相关方法，具有对线粒体的特定选择性。该化合物包括一个附着在线粒体靶向基团上的亚硝基含有基团。该化合物可以交联成二聚体而不损失活性。本文还提供了一种预防、缓解和治疗辐射引起的损伤的方法。该方法包括向患者输送如本文所述的化合物，以有效预防、缓解或治疗辐射引起的损伤，该化合物的用量和剂量方案。
• US5143936A
  申请人：——

  公开号：US5143936A

  公开（公告）日：1992-09-01
• US8487079B2
  申请人：——

  公开号：US8487079B2

  公开（公告）日：2013-07-16