(2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydron;chloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydron;chloride
• 化学式: C22H25ClN2O8
• 分子量: 480.9
• InChiKey: DYQBMRZOOXYHIM-NCKOGSTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.05
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  182
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS
  申请人：Evonik Degussa GmbH

  公开号：EP3456833A1

  公开（公告）日：2019-03-20

  The present invention provides provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-ornithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.

  本发明提供了一种棒状杆菌属细菌，特别是谷氨酸棒状杆菌属细菌，该细菌具有排泄选自蛋白源L-氨基酸和L-鸟氨酸的L-氨基酸的能力，以及利用这种细菌发酵生产蛋白源L-氨基酸和L-鸟氨酸的新措施。
• PHOTOTOXICITY OR PHOTOALLERGY MEASUREMENT METHOD AND REAGENT FOR USE IN SAID MEASUREMENT METHOD
  申请人：FUJIFILM Corporation

  公开号：EP3901620A1

  公开（公告）日：2021-10-27

  Provided are a method for measuring the phototoxicity or photoallergy of a test substance without using animals and a reagent for use therein. The method for measuring phototoxicity or photoallergy includes reacting a test substance with an organic compound that is an N-(arylalkylcarbonyl)cysteine or an α-N-(arylalkylcarbonyl)lysine under irradiation with ultraviolet light; reacting the test substance with the organic compound without irradiation with ultraviolet light; determining the depletion of the organic compound after each reaction by an optical measurement; and detecting phototoxicity or photoallergy from the difference between the depletion of the organic compound after the reaction under irradiation with ultraviolet light and the depletion of the organic compound after the reaction without irradiation with ultraviolet light.

  本发明提供了一种不使用动物而测量受试物质光毒性或光过敏性的方法以及用于该方法的试剂。这种测量光毒性或光过敏性的方法包括：在紫外线照射下，使受试物质与 N-(芳基烷基羰基)半胱氨酸或 α-N-(芳基烷基羰基)赖氨酸的有机化合物反应；在没有紫外线照射的情况下，使受试物质与有机化合物反应；通过光学测量确定每次反应后有机化合物的损耗量；根据在紫外线照射下反应后有机化合物的损耗量与在未用紫外线照射的情况下反应后有机化合物的损耗量之间的差值检测光毒性或光过敏性。
• Method for the fermentative production of L-amino acids
  申请人：EVONIK DEGUSSA GMBH

  公开号：US10683511B2

  公开（公告）日：2020-06-16

  The present invention provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-omithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.

  本发明提供了一种棒状杆菌属细菌，特别是谷氨酸棒状杆菌属细菌，该细菌具有排泄选自蛋白源L-氨基酸和L-鸟氨酸的L-氨基酸的能力，以及利用这种细菌发酵生产蛋白源L-氨基酸和L-鸟氨酸的新措施。
• Method for determining genotoxicity
  申请人：Allard David John

  公开号：US20060110768A1

  公开（公告）日：2006-05-25

  Methods and reagents for determining the genotoxicity of a compound based on genomic responses to contact therewith are provided.

  提供了根据基因组对与化合物接触的反应确定化合物遗传毒性的方法和试剂。
• A FORWARD MUTATION ASSAY BASED ON 5-FLUOROURACIL RESISTANCE
  申请人：Merck & Co., Inc.

  公开号：EP1620569A2

  公开（公告）日：2006-02-01