2-{[6-(4-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-yl]sulfanyl}-N-(naphthalen-1-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-{[6-(4-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-yl]sulfanyl}-N-(naphthalen-1-yl)acetamide
• 英文别名: 2-[[6-(4-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-yl]sulfanyl]-N-naphthalen-1-ylacetamide
• 化学式: C₂₈H₂₂N₄O₂S
• mdl: MFCD03765075
• 分子量: 478.6
• InChiKey: VEDPXSVDRUYCBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14
  申请人：THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE

  公开号：US20160146784A1

  公开（公告）日：2016-05-26

  The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.
• US9238034B2
  申请人：——

  公开号：US9238034B2

  公开（公告）日：2016-01-19
• US9797882B2
  申请人：——

  公开号：US9797882B2

  公开（公告）日：2017-10-24