(Z)-1-((2,4-dioxochroman-3-ylidene)methyl)urea | 81153-74-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (Z)-1-((2,4-dioxochroman-3-ylidene)methyl)urea
• 英文别名: [(Z)-(2,4-dioxochromen-3-ylidene)methyl]urea
• CAS: 81153-74-4
• 化学式: C₁₁H₈N₂O₄
• 分子量: 232.196
• InChiKey: LWGSKPKQSNQWNW-ALCCZGGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Honokiol Derivates For the Treatment of Proliferative Disorders
  申请人：Arbiser Jack L.

  公开号：US20080300298A1

  公开（公告）日：2008-12-04

  The present invention provides novel honokiol derivatives, as well as pharmaceutical compositions containing the honokiol derivatives. These compounds and pharmaceutical compositions can be used in the prevention and/or treatment of cancer. In particular, honokiol derivatives, pharmaceutical compositions comprising the derivatives, and methods for their use in the treatment of myeloma are provided.
• [EN] COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS<br/>[FR] COMPOSÉS QUI DÉVELOPPENT DES CELLULES SOUCHES HÉMATOPOÏÉTIQUES
  申请人：IRM LLC

  公开号：WO2012102937A2

  公开（公告）日：2012-08-02

  The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.