1,2,3,4,5-pentafluoro-6-[2-(3-nitrophenyl)ethenyl]benzene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,2,3,4,5-pentafluoro-6-[2-(3-nitrophenyl)ethenyl]benzene
• 英文别名: (E)-1-pentafluorophenyl-2-(3'-nitrophenyl)ethene；1,2,3,4,5-pentafluoro-6-[(E)-2-(3-nitrophenyl)ethenyl]benzene
• 化学式: C₁₄H₆F₅NO₂
• 分子量: 315.199
• InChiKey: RGWJOBSQLOJLLO-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三苯基膦 、 α-溴-2,3,4,5,6-五氟甲基苯酸酯 在 18-冠醚-6 、 potassium carbonate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 1,2,3,4,5-pentafluoro-6-[2-(3-nitrophenyl)ethenyl]benzene 、 1,2,3,4,5-pentafluoro-6-[2-(3-nitrophenyl)ethenyl]benzene
  参考文献：
  名称：

  Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists

  摘要：

  Novel dipeptidyl peptidase IV (DPP-IV) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on alpha-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Representative compounds showed non-competitive inhibition of DPP-IV and 28a exhibited 10-fold selectivity for DPP-IV over DPP-8. Compound 28a is the first non-competitive, selective DPP-IV inhibitor. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.026

文献信息

• Kamigata, Nobumasa; Yoshikawa, Manabu; Shimizu, Toshio, Phosphorus, Sulfur and Silicon and the Related Elements, 1998, vol. 134-135, p. 11 - 20
  作者：Kamigata, Nobumasa、Yoshikawa, Manabu、Shimizu, Toshio

  DOI：——

  日期：——
• Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists
  作者：Kazunori Motoshima、Kazuyuki Sugita、Yuichi Hashimoto、Minoru Ishikawa

  DOI：10.1016/j.bmcl.2011.03.026

  日期：2011.5

  Novel dipeptidyl peptidase IV (DPP-IV) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on alpha-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Representative compounds showed non-competitive inhibition of DPP-IV and 28a exhibited 10-fold selectivity for DPP-IV over DPP-8. Compound 28a is the first non-competitive, selective DPP-IV inhibitor. (C) 2011 Elsevier Ltd. All rights reserved.