trans-1-Phenyl-aethen-2-sulfonsaeure- | 13719-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: trans-1-Phenyl-aethen-2-sulfonsaeure-
• 英文别名: Naphthalen-2-yl 2-phenylethenesulfonate；naphthalen-2-yl (E)-2-phenylethenesulfonate
• CAS: 13719-35-2
• 化学式: C₁₈H₁₄O₃S
• 分子量: 310.373
• InChiKey: LATGHFGQZUSPBC-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Vinylsulfonate and vinylsulfonamide compounds
  申请人：Lee Shiow-Ju

  公开号：US20070135469A1

  公开（公告）日：2007-06-14

  A method for activating PPARγ or inhibiting NO production with an effective amount of a vinylsulfonate or vinylsulfonamide compound of the following formula: wherein Ar 1 is aryl or heteroaryl, each of R 1 , R 2 , and R 3 , independently, is hydrogen, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, X is O or NR, R being hydrogen, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, and n is 0, 1, 2, 3, or 4. This invention also covers a method of treating a NO-related disease or PPARγ-related disease with such a vinylsulfonate or vinylsulfonamide compound.