N-dodecanoylsphingosine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-dodecanoylsphingosine
• 英文别名: N-lauroyl-sphingosine；N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide
• 化学式: C₃₀H₅₉NO₃
• 分子量: 481.803
• InChiKey: HXFPPRPLRSPNIB-WJTDDFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  34
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  D-erythro-sphingosine 、 Sodium laurate 在 N,N-dimethylglycine hexadecyl ester 、 Rh-PE fluorescent dye 2-氯-4,6-二甲氧基-1,3,5-三嗪 、 phosphatidylcholine 作用下， 以 甲醇 、 phosphate buffer 、 氯仿 为溶剂， 反应 24.0h， 生成 N-dodecanoylsphingosine
  参考文献：
  名称：

  Spontaneous Membrane Fusion Induced by Chemical Formation of Ceramides in a Lipid Bilayer

  摘要：

  Mere chemical generation of ceramide and related double-chain lipids in the membrane of small unilamellar vesicles (SUVs) induces fusion of the vesicles. The lipids can be successfully prepared by dehydrocondensation between single-chain lipids (fatty acids and sphingosine or its analogues) in a lipid bilayer of the SUV by using a combination of 2-chloro-4,6-dimethoxy-1,3,5-triazine and amphiphilic tertiary amine catalysts, a process that can be compared to a successive enzyme model system for a fatty acyl-CoA synthetase followed by acyltransferase. The SUV spontaneously undergoes membrane fusion upon this internal chemical stimulation by the artificial enzyme system.

  DOI：

  10.1021/ja0652969

文献信息

• CERAMIDASE GENE
  申请人：Takara Shuzo Co, Ltd.

  公开号：EP1172436A1

  公开（公告）日：2002-01-16

  A neutral/alkaline ceramidase derived from a mammal; an antibody specifically binding thereto; a probe and primer which are capable of specifically hybridizing thereto; a method for producing the ceramidase by a genetic engineering means; a method for detecting the ceramidase or the gene; and a method of controlling an amount of a ceramide in a cell and/or in a tissue. The present invention is useful as a reagent for lipid engineering for analyzing a structure, functions, and the like of a ceramide, and in its applications to diseases associated with the ceramide metabolism.

  一种来源于哺乳动物的中性/碱性神经酰胺酶；一种与之特异性结合的抗体；一种能够与之特异性杂交的探针和引物；一种通过基因工程手段生产神经酰胺酶的方法；一种检测神经酰胺酶或基因的方法；以及一种控制细胞和/或组织中神经酰胺数量的方法。本发明作为一种脂质工程试剂，可用于分析神经酰胺的结构、功能等，并可应用于与神经酰胺代谢有关的疾病。
• ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3777891A1

  公开（公告）日：2021-02-17

  Provided are an artificially synthesized sphingosine lipoid monomer and the use of same for delivering a nucleic acid. In particular, provided is the use or a method of using a compound of formula I, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, or a combination comprising the compound of formula I, the stereoisomer thereof or the pharmaceutically acceptable salt thereof to deliver a nucleic acid to a cell or subject, (I)

  本发明提供了一种人工合成的鞘氨醇类脂质单体及其用于递送核酸的用途。特别是，提供了使用式 I 的化合物、其立体异构体或其药学上可接受的盐，或包含式 I 的化合物、其立体异构体或其药学上可接受的盐的组合物向细胞或受试者递送核酸的用途或方法，(I)
• AZIDO COMPOUNDS AND METHOD FOR MONITORING ACID CERAMIDASE ACTIVITY IN INTACT CELLS USING THEM
  申请人：Consejo Superior de Investigaciones Científicas (CSIC)

  公开号：EP3925949A1

  公开（公告）日：2021-12-22

  The application relates to azido compounds of formula (I) and a method of using them together with a fluorogenic reporter as a click agent for the specific determination of acid ceramidase activity in intact cells. The application also relates to a kit to carry out said method and the use thereof for the diagnosis of a disease caused by the deregulation of ceramidase activity selected from Farber disease and cancer.

  本申请涉及式（I）的叠氮化合物，以及将它们与含氟报告物一起作为点击剂用于特异性测定完整细胞中酸性神经氨酸酶活性的方法。本申请还涉及一种用于实施上述方法的试剂盒及其在诊断由神经氨酸酶活性失调引起的疾病时的用途，该疾病选自法伯病和癌症。
• Drug-coated balloon catheters for body lumens
  申请人：Urotronic, Inc.

  公开号：US10806830B2

  公开（公告）日：2020-10-20

  Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

  所公开的各种实施方案涉及用于治疗体腔狭窄的药物涂层球囊导管及其使用方法。一种用于向体腔狭窄的目标部位输送治疗剂的药物涂层球囊导管包括一个具有主直径的细长球囊。球囊导管包括覆盖在球囊外表面的涂层。涂层包括一种或多种水溶性添加剂和治疗剂的初始药物负荷。
• Balloon catheters for body lumens
  申请人：Urotronic, Inc.

  公开号：US10850076B2

  公开（公告）日：2020-12-01

  Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

  所公开的各种实施方案涉及用于治疗体腔狭窄的药物涂层球囊导管及其使用方法。一种用于向体腔狭窄的目标部位输送治疗剂的药物涂层球囊导管包括一个具有主直径的细长球囊。球囊导管包括覆盖在球囊外表面的涂层。涂层包括一种或多种水溶性添加剂和治疗剂的初始药物负荷。