rac-2-fluoro-N-(2-methylimidazo[1,2-a]pyridin-6-yl)-4-(3-methylpiperazin-1-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: rac-2-fluoro-N-(2-methylimidazo[1,2-a]pyridin-6-yl)-4-(3-methylpiperazin-1-yl)benzamide
• 英文别名: 2-fluoro-N-(2-methylimidazo[1,2-a]pyridin-6-yl)-4-(3-methylpiperazin-1-yl)benzamide
• 化学式: C₂₀H₂₂FN₅O
• 分子量: 367.426
• InChiKey: CDFYPSURDFQWHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,4-difluoro-N-(2-methylimidazo[1,2-a]pyridin-6-yl)benzamide 、 2-甲基哌嗪 以 N,N-二甲基乙酰胺 为溶剂， 反应 1.5h， 生成 rac-2-fluoro-N-(2-methylimidazo[1,2-a]pyridin-6-yl)-4-(3-methylpiperazin-1-yl)benzamide
  参考文献：
  名称：

  [EN] COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  [FR] COMPOSÉS POUR LE TRAITEMENT D'UNE AMYOTROPHIE SPINALE

  摘要：

  公开号：

  WO2014209841A3

文献信息

• COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20160145270A1

  公开（公告）日：2016-05-26

  The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明提供了式（I）化合物，其中A、B、X、Y、R1和R2如本文所述，以及其药学上可接受的盐。此外，本发明涉及制备式（I）化合物，包括它们的药物组合物以及它们作为药物的用途。
• [EN] COMPOUNDS FOR USE IN TREATING HUNTINGTON'S DISEASE<br/>[FR] COMPOSÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA MALADIE DE HUNTINGTON
  申请人：PTC THERAPEUTICS INC

  公开号：WO2021007378A1

  公开（公告）日：2021-01-14

  The present description relates to a use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating Huntington's Disease (HD) in a subject in need thereof comprising, administering to the subject an effective amount of the compound of Formula (I): wherein A, B, X, Y, R1 and R2 are as defined herein, or a form or composition thereof. The present description further relates to the use of a monocyclic aromatic amido substituted compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering to the subject an effective amount of the compound of Formula (I) or a form or composition thereof.
• [EN] COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'UNE AMYOTROPHIE SPINALE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014209841A3

  公开（公告）日：2015-10-29