(R)-[2-(1,3,5-dithiazinan-5-yl)butoxy]methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环化合物
• 英文名称: (R)-[2-(1,3,5-dithiazinan-5-yl)butoxy]methanol
• 英文别名: (r)-[2-(1,3,5-Dithiazinan-5-yl)butoxy]meth-anol；[(2R)-2-(1,3,5-dithiazinan-5-yl)butoxy]methanol
• 化学式: C₈H₁₇NO₂S₂
• 分子量: 223.36
• InChiKey: CGZLPAGAIHOFPV-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  83.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 2-氨基丁醇 在 硫化氢 作用下， 以 水 为溶剂， 以52%的产率得到(R)-[2-(1,3,5-dithiazinan-5-yl)butoxy]methanol
  参考文献：
  名称：

  Thiomethylation of amino alcohols using formaldehyde and hydrogen sulfide

  摘要：

  Three-component condensations of formaldehyde with hydrogen sulfide and hydroxylamine or amino alcohols at a ratio of 3:2:1 give 47-73% of N-hydroxy(or hydroxyalkyl)-1,3,5-dithiazinanes. The reactions of CH2O with H2S and hydroxylamine or alpha-amino alcohols at a ratio of 4:3:1 involve both amino and hydroxy groups, leading to the corresponding dithiazinanes. 4-Aminobutan-1-ol reacts with CH2O and H2S under analogous conditions only at the amino group to form 4-(1,3,5-dithiazinan-5-yl)butan-1-ol.

  DOI：

  10.1134/s1070428007060218

文献信息

• Thiomethylation of amino alcohols using formaldehyde and hydrogen sulfide
  作者：V. R. Akhmetova、G. R. Nadyrgulova、T. V. Tyumkina、Z. A. Starikova、M. Yu. Antipin、R. V. Kunakova、U. M. Dzhemilev

  DOI：10.1134/s1070428007060218

  日期：2007.6

  Three-component condensations of formaldehyde with hydrogen sulfide and hydroxylamine or amino alcohols at a ratio of 3:2:1 give 47-73% of N-hydroxy(or hydroxyalkyl)-1,3,5-dithiazinanes. The reactions of CH2O with H2S and hydroxylamine or alpha-amino alcohols at a ratio of 4:3:1 involve both amino and hydroxy groups, leading to the corresponding dithiazinanes. 4-Aminobutan-1-ol reacts with CH2O and H2S under analogous conditions only at the amino group to form 4-(1,3,5-dithiazinan-5-yl)butan-1-ol.