dimethyl-{2-[3-(1-oxa-8-thia-3-aza-dibenzo[e,h]azulene-2-yl)-propoxy]-ethyl}-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: dimethyl-{2-[3-(1-oxa-8-thia-3-aza-dibenzo[e,h]azulene-2-yl)-propoxy]-ethyl}-amine
• 英文别名: N,N-dimethyl-2-[3-(3-oxa-13-thia-5-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2(6),4,7,9,11,14,16-octaen-4-yl)propoxy]ethanamine
• 化学式: C₂₂H₂₄N₂O₂S
• 分子量: 380.511
• InChiKey: KRRBJHCKCOENGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  63.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (1-oxa-8-thia-3-aza-dibenzo[e,h]azulene-2-yl)-propane-1-ol 、 二甲氨基氯乙烷盐酸 在 苄基三乙基氯化铵 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 4.0h， 生成 dimethyl-{2-[3-(1-oxa-8-thia-3-aza-dibenzo[e,h]azulene-2-yl)-propoxy]-ethyl}-amine
  参考文献：
  名称：

  [EN] 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF
  [FR] 1-OXA-3-AZA-DIBENZOAZULENES UTILISES COMME INHIBITEURS DE LA PRODUCTION DU FACTEUR DE NECROSE TUMORALE, ET INTERMEDIAIRES DESTINES A LA PRODUCTION DE CES DERNIERS

  摘要：

  本发明涉及1-氧杂-3-氮杂二苯并蓝类衍生物，其药理学上可接受的盐和溶剂化合物，以及其制备的过程和中间体，特别是其抗炎作用，尤其是对肿瘤坏死因子-α（TNF-α）产生的抑制作用和对白细胞介素-1（IL-1）产生的抑制作用，以及其镇痛作用。

  公开号：

  WO2003084964A1

文献信息

• 1-Oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
  申请人：Mercep Mladen

  公开号：US20050148576A1

  公开（公告）日：2005-07-07

  The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1-氧杂-3-氮杂二苯并蓝类衍生物，其药理学上可接受的盐和溶剂，以及其制备过程和中间体，以及它们的抗炎作用，特别是对肿瘤坏死因子-α（TNF-α）产生的抑制和白细胞介素-1（IL-1）产生的抑制，以及它们的镇痛作用。
• 1-oxa 3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
  申请人：Mercep Mladen

  公开号：US20050130956A1

  公开（公告）日：2005-06-16

  The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1-氧杂-3-氮杂-二苯并蓝类衍生物，其药物学上可接受的盐和溶剂，其制备过程和中间体，以及其抗炎作用，特别是抑制肿瘤坏死因子-α（TNF-α）的产生和抑制白细胞介素-1（IL-1）的产生，以及其镇痛作用。
• 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF
  申请人：PLIVA-ISTRAZIVACKI INSTITUT d.o.o.

  公开号：EP1492797A1

  公开（公告）日：2005-01-05
• USE OF 3-AZA-1-OXA-DIBENZO i e,h /i AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEAS AND DISORDERS
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1684766B1

  公开（公告）日：2007-06-27
• 3-Aza-1-oxa-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders
  申请人：Mercep Mladen

  公开号：US20070111990A1

  公开（公告）日：2007-05-17

  The present invention relates to the use of compounds from the group of 3-aza-1-oxa-dibenzo[e,h]azulenes and of their pharmacologically acceptable salts and solvates for the use in the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.