bis<(bromozincio)methylene>zinc

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: bis<(bromozincio)methylene>zinc
• 英文别名: Nysted reagent；bis[(bromozincio)methylene]zinc；Nysted-reagent
• 化学式: C₂H₄Br₂Zn₃
• 分子量: 384.032
• InChiKey: KPOHTTDLEIPUKQ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  7.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  bis<(bromozincio)methylene>zinc 、 大豆皂醇 E 在 四氯化钛 作用下， 以 四氢呋喃 为溶剂， 以52%的产率得到(3S,4S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-9-methylidene-2,3,4a,5,6,7,8,10,12,12a,14,14a-dodecahydro-1H-picen-3-ol
  参考文献：
  名称：

  Efficient synthesis of C(22) homologous derivatives of hepatoprotective soyasapogenol B

  摘要：

  Stereochemical behavior in the addition reactions at C(22) of ketone 5 and exomethylene 6 was studied and C(22) homologous derivatives of soyasapogenol B were efficiently synthesized (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10256-8

文献信息

• Enantioselective Synthesis of a <i>trans</i>-7,8-Dimethoxycalamenene
  作者：Susen Werle、Thorsten Fey、Jörg M. Neudörfl、Hans-Günther Schmalz

  DOI：10.1021/ol071228v

  日期：2007.8.1

  projected intermediate for the total synthesis of marine serrulatane and amphilectane diterpenes, was efficiently synthesized. Starting from a styrene, asymmetric Rh-catalyzed hydroboration using a novel chiral P,P-bidentate ligand afforded an organoboron intermediate (93% ee) which was directly used for C-C bond formation (double homologation, Suzuki coupling). The 1,4-trans-disubstituted tetralin skeleton

  有效合成了反式7,8-二甲氧基-11,12-脱氢cal草烯，这是一种预计合成的全合成海洋型斯拉拉坦烷和两性烷二萜烯的中间体。从苯乙烯开始，使用新型手性P，P-二齿配体的不对称Rh催化的硼氢化反应提供了有机硼中间体（93％ee），该中间体可直接用于CC键的形成（双重同源性，Suzuki偶联）。1,4-反式二取代的四氢萘骨架是在严格非质子条件下（Me2AlCl）通过Friedel-Crafts型阳离子环化选择性形成的，以通过非对映选择性氢化物转移抑制质子催化的歧化反应。
• Synthesis and structure-activity relationships of acyclic .omega. chain conjugated diene analogs of enisoprost
  作者：P. W. Collins、R. L. Shone、W. E. Perkins、A. F. Gasiecki、V. J. Kalish、S. W. Kramer、R. G. Bianchi

  DOI：10.1021/jm00082a010

  日期：1992.2

  of acyclic omega chain conjugated diene analogues of enisoprost were synthesized and evaluated for gastric antisecretory and diarrheagenic activities in comparison to enisoprost and a previously identified cyclic dienyl analogue. Several novel approaches to the cuprate reagents involved in the synthesis of the series are described. From this SAR study, it appears that both the conjugated diene and

  合成了一系列依诺前列素的无环ω链共轭二烯类似物，并与依诺前列素和先前鉴定的环状二烯基类似物相比，评估了胃的抗分泌和腹泻活性。描述了用于合成该系列的铜酸盐试剂的几种新颖方法。从这项SAR研究中，似乎共轭二烯和欧米茄链的整体空间填充特性都是这些化合物的药理作用和选择性的重要组成部分，并且不需要环状结构。
• Anderson, James C.; Pearson, David J., Journal of the Chemical Society. Perkin transactions I, 1998, # 13, p. 2023 - 2029
  作者：Anderson, James C.、Pearson, David J.

  DOI：——

  日期：——
• Total Synthesis of Amphidinolide T4
  作者：Alois Fürstner、Christophe Aïssa、Ricardo Riveiros、Jacques Ragot

  DOI：10.1002/anie.200290042

  日期：2002.12.16
• A Concise and Stereoselective Synthesis of the A-Ring Fragment of the Gambieric Acids
  作者：J. Stephen Clark、Thomas C. Fessard、Claire Wilson

  DOI：10.1021/ol049483s

  日期：2004.5.1

  The A-ring fragment of the gambieric acids has been prepared by a short and efficient route. The key 3(2H)-furanone intermediate has been obtained by [2,3] rearrangement of an allylic oxonium ylide generated from intramolecular reaction of a crotyl ether with a copper carbenoid. A single stereogenic center has been set by using a chiral pool starting material and the other three have been established by using highly diastereoselective substrate-controlled transformations.