6-(2-carboxyphenyl)-9-(diethylamino)-3,4-dihydro-2H-chromeno[3,2-g]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-(2-carboxyphenyl)-9-(diethylamino)-3,4-dihydro-2H-chromeno[3,2-g]quinoline
• 英文别名: 2-[9-(diethylamino)-3,4-dihydro-2H-chromeno[3,2-g]quinolin-6-yl]benzoic acid
• 化学式: C₂₇H₂₆N₂O₃
• 分子量: 426.515
• InChiKey: RVFAMLDPOMBFEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-羟基-1,2,3,4-四氢喹啉 、 4-二乙氨基酮酸 在 甲烷磺酸 作用下， 以74.6%的产率得到6-(2-carboxyphenyl)-9-(diethylamino)-3,4-dihydro-2H-chromeno[3,2-g]quinoline
  参考文献：
  名称：

  Spectrofluorimetric determination of trace nitrite with a novel fluorescent probe

  摘要：

  A simple, sensitive and selective fluorimetric determination for trace nitrites was developed using an unsymmetrical rhodamine with a high fluorescence quantum yield and large Stokes shift. The method is based on the reaction of the unsymmetrical rhodamine with nitrite in an acidic medium to form a nitroso product, which has much lower fluorescence because the electron-withdrawing effect of the nitroso group influences the system of p-pi conjugation between N atom and benzene ring. Under optimum conditions, the fluorescence quenching intensity is linear over a nitrite concentration range of 1.0 x 10(-8) to 3.5 x 10(-7) M. The detection limit is 2.0 x 10(-10) M (S/N = 3). The method was applied to the determination of nitrite in tap water and lake water with satisfactory results. The mechanism for the reaction is also reported. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2009.03.018

文献信息

• Spectrofluorimetric determination of trace nitrite with a novel fluorescent probe
  作者：Qing-Hao Liu、Xi-Long Yan、Jin-Chun Guo、Dong-Hua Wang、Lei Li、Fan-Yong Yan、Li-Gong Chen

  DOI：10.1016/j.saa.2009.03.018

  日期：2009.9

  A simple, sensitive and selective fluorimetric determination for trace nitrites was developed using an unsymmetrical rhodamine with a high fluorescence quantum yield and large Stokes shift. The method is based on the reaction of the unsymmetrical rhodamine with nitrite in an acidic medium to form a nitroso product, which has much lower fluorescence because the electron-withdrawing effect of the nitroso group influences the system of p-pi conjugation between N atom and benzene ring. Under optimum conditions, the fluorescence quenching intensity is linear over a nitrite concentration range of 1.0 x 10(-8) to 3.5 x 10(-7) M. The detection limit is 2.0 x 10(-10) M (S/N = 3). The method was applied to the determination of nitrite in tap water and lake water with satisfactory results. The mechanism for the reaction is also reported. (C) 2009 Elsevier B.V. All rights reserved.