吡啶并[2,3-e][1,2,4]三嗪 | 254-97-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 吡啶并[2,3-e][1,2,4]三嗪
• 英文名称: Pyrido<2,3-e>-as-triazine
• 英文别名: Pyrido[2,3-e][1,2,4]triazine
• CAS: 254-97-7
• 化学式: C₆H₄N₄
• 分子量: 132.125
• InChiKey: GHKGSHZMWWDYKI-UHFFFAOYSA-N

物化性质

• 熔点：
  130 °C
• 沸点：
  256.1±13.0 °C(Predicted)
• 密度：
  1.369±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基-2-硝基吡啶 在 palladium on activated charcoal tetrafluoroboric acid 、 氢气 、 一水合肼 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 反应 10.62h， 生成 吡啶并[2,3-e][1,2,4]三嗪
  参考文献：
  名称：

  Ple, N.; Queguiner, G., Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 475 - 476

  摘要：

  DOI：

文献信息

• [EN] FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES<br/>[FR] FONGICIDES FONDES SUR DES HETEROCYCLES CONTENANT DE L'AZOTE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2005123698A1

  公开（公告）日：2005-12-29

  The compound of the general formula (I), wherein W, X, Y, Z, R, R1 and R2 are defined as set forth in the specification, useful as fungicide.

  通式（I）的化合物，其中W、X、Y、Z、R、R1和R2如规范中所定义，可用作杀菌剂。
• [EN] MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE<br/>[FR] MONOBACTAMES ET PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION DE CES DERNIERS
  申请人：HARVARD COLLEGE

  公开号：WO2015103583A1

  公开（公告）日：2015-07-09

  Described herein are monobactam antibiotics of Formula (I), (Ι'), (II), and (II'), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.

  本文描述了单环内酰胺抗生素的化学式(I)、(Ι')、(II)和(II')，以及制备这些化合物的方法和中间体。还提供了使用单环内酰胺治疗传染病的药物组合物和方法。
• Fungicides based on nitrogen-containing heterocycles
  申请人：Crowley Jelf Patrick

  公开号：US20060100203A1

  公开（公告）日：2006-05-11

  Fungicidal compounds having the general formula (1): formula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR 8 ; R 8 is H, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio or halo(C 1-4 )alkyl; R and R 2 are independently H, halo, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylthio, C 2-8 alkenyl, C 2-8 alkynyl, cyano or NR 3 R 4 , provided that at least one of R and R 2 is NR 3 R 4 ; R 1 is halo, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )-alkyl, C 1-8 alkoxy, C 1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C 1-4 )alkyl, aryl(C 1-4 )alkoxy, heteroaryl(C 1-4 )alkyl, heteroaryl(C 1-4 )alkoxy, aryl(C 1-4 )alkylthio, heteroaryl(C 1-4 )alkylthio, morpholino, piperidino or pyrrolidino; R 3 and R 4 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, aryl(C 1-8 )-alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl, heteroaryl(C 1-8 )alkyl, NR 5 R 6 , provided that not both R 3 and R 4 are H or NR 5 R 6 , or R 3 and R 4 together form a C 3-7 alkylene or C 3-7 alkenylene chain optionally substituted with one or more C 1-4 alkyl or C 1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R 3 and R 4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C 1-4 )alkyl (especially N-methyl) ring; and R 5 and R 6 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 -alkynyl, aryl, aryl(C 1-8 )alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-8 )alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R 8 ) being optionally substituted with halogen, cyano, C 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 haloalkoxy, C 1-6 alkylthio, tri(C 1-4 )alkylsilyl, C 1-6 alkylamino or C 1-6 dialkylamino, any of the foregoing morpholine, thiomopholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C 1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, halo(C 1-6 )alkyl, halo(C 1-6 )alkoxy, C 1-6 alkylthio, halo(C 1-6 )alkylthio, hydroxy(C 1-6 )alkyl, C 1-4 alkoxy(C 1-6 )alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NR″′R″″, NHCOR″′, —NHCONR″′R″″, —CONR″′R″″, —SO 2 R″′, —OSO 2 R″′, —COR″′, —CR″′═NR″″ or —N═CR ″′R″″, in which R″′ and R″″ are independently hydrogen, C 1-4 alkyl, halo(C 1-4 )alkyl, C 1-4 alkoxy, halo(C 1-4 )alkoxy, C 1-4 alkylthio, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C 1-4 alkyl or C 1-4 alkoxy.

  具有通式（1）的杀菌化合物：通式（1）其中，W，Z和X和Y中的另一个是CR8，另一个是N；R8为H，卤素，C1-4烷基，C1-4烷氧基，C1-4烷硫基或卤素（C1-4）烷基；R和R2独立地为H，卤素，C1-8烷基，C1-8烷氧基，C1-8烷硫基，C2-8烯基，C2-8炔基，氰基或NR3R4，但其中至少一个为NR3R4；R1为卤素，C1-8烷基，C2-8烯基，C2-8炔基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，C1-8烷氧基，C1-8烷硫基，芳基，芳氧基，芳硫基，杂环芳基，杂环芳氧基，杂环芳硫基，芳基（C1-4）烷基，芳基（C1-4）烷氧基，杂环芳基（C1-4）烷基，杂环芳基（C1-4）烷氧基，芳基（C1-4）烷硫基，杂环芳基（C1-4）烷硫基，吗啉基，哌啶基或吡咯烷基；R3和R4独立地为H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）烷基，杂环芳基，杂环芳基（C1-8）烷基，NR5R6，但不是R3和R4都为H或NR5R6，或者R3和R4一起形成一个C3-7烷基或C3-7烯基链，可选择地取代一个或多个C1-4烷基或C1-4烷氧基，或者与它们所附着的氮原子一起，R3和R4形成吗啉，硫代吗啉，硫代吗啉S-氧化物或硫代吗啉S-二氧化物环或哌嗪或哌嗪N-（C1-4）烷基（特别是N-甲基）环；R5和R6独立地为H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）烷基，杂环芳基或杂环芳基（C1-8）烷基；除R8之外的任何上述烷基，烯基，炔基或环烷基基团（均可选择地取代卤素，氰基，C1-6烷氧基，C1-6烷基羰基，C1-6烷氧羰基，C1-6卤烷氧基，C1-6烷硫基，三（C1-4）烷基硅烷基，C1-6烷基氨基或C1-6二烷基氨基），任何上述吗啉，硫代吗啉，哌嗪，哌嗪和吡咯烷环可选择地取代C1-4烷基（特别是甲基），任何上述芳基或杂环芳基基团可选择地取代一个或多个取代基，所述取代基选自卤素，羟基，巯基，C1-6烷基，C2-6烯基，C2-6炔基，C1-6烷氧基，C2-6烯氧基，C2-6炔氧基，卤素（C1-6）烷基，卤素（C1-6）烷氧基，C1-6烷硫基，卤素（C1-6）烷硫基，羟基（C1-6）烷基，C1-4烷氧基（C1-6）烷基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯氧基，苄氧基，苯甲酰氧基，氰基，异氰基，硫氰酸基，异硫氰酸基，硝基，—NR″′R″″，NHCOR″′，—NHCONR″′R″″，—CONR″′R″″，—SO2R″′，—OSO2R″′，—COR″′，—CR″′═NR″″或—N═CR″′R″″，其中R″′和R″″独立地为氢，C1-4烷基，卤素（C1-4）烷基，C1-4烷氧基，卤素（C1-4）烷氧基，C1-4烷硫基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯基或苄基，苯基和苄基可选择地取代卤素，C1-4烷基或C1-4烷氧基。
• Fungicides Based on Nitrogen-Containing Heterocycles
  申请人：Crowley Patrick Jelf

  公开号：US20080318962A1

  公开（公告）日：2008-12-25

  The compound of the general formula (I), wherein W, X, Y, Z, R, R 1 and R 2 are defined as set forth in the specification, useful as fungicide.

  通式（I）的化合物，其中W、X、Y、Z、R、R1和R2如规范所述定义，可用作杀真菌剂。
• Electrochromic devices
  申请人：CHEVRON RESEARCH AND TECHNOLOGY COMPANY

  公开号：EP0145337A2

  公开（公告）日：1985-06-19

  An electrochromic device (10) incorporates a reversibly colour-changing organic polymer film (20) as part of the display electrode. The display polymer film (20) is capable of undergoing reversible oxidation and/or reduction to a charged, coloured, conductive state. Upon reversing the charge, the polymer returns to its virgin colour. The display films are comprised of linear fused heterocyclic ring systems, optionally with connecting units, or linear monocyclic ring systems and connecting units. The device requires low currents to operate and switch from the virgin state to the coloured state. It also can optionally be operated to exhibit several colours.

  一种电致变色装置（10）将可逆变色有机聚合物薄膜（20）作为显示电极的一部分。 显示聚合物薄膜（20）能够进行可逆氧化和/或还原，变成带电、有色、导电的状态。 一旦电荷反转，聚合物就会恢复原色。 显示薄膜由线性融合杂环环系统（可选择带连接单元）或线性单环环系统和连接单元组成。 该装置只需较低的电流即可运行并从原色状态切换到有色状态。 它还可选择运行以显示多种颜色。