1-bromo-3,5-dimethylcyclohexane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1-bromo-3,5-dimethylcyclohexane
• 英文别名: 1-Brom-3,5-dimethyl-cyclohexan
• 化学式: C₈H₁₅Br
• 分子量: 191.111
• InChiKey: PWECRZWUPVQPSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-bromo-3,5-dimethylcyclohexane 在 乙醇 、 锌 作用下， 生成 1,3-二甲基环己烷
  参考文献：
  名称：

  v. Auwers; Hinterseber; Treppmann, Justus Liebigs Annalen der Chemie, 1915, vol. 410, p. 267

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二甲基环己醇 在 三溴化磷 作用下， 生成 1-bromo-3,5-dimethylcyclohexane
  参考文献：
  名称：

  v. Auwers; Hinterseber; Treppmann, Justus Liebigs Annalen der Chemie, 1915, vol. 410, p. 267

  摘要：

  DOI：

文献信息

• [EN] 1,2,4-THIADIAZOLE COMPOUNDS AND ARTHROPOD CONTROLLING COMPOSITION CONTAINING THE SAME<br/>[FR] COMPOSES A BASE DE 1,2,4-THIADIAZOLE ET COMPOSITION ANTI-ARTHROPODES LES CONTENANT
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2004046125A1

  公开（公告）日：2004-06-03

  The present invention relates to a novel 1,2,4-thiadiazole compound represented by the formula (1): wherein, R1 represents C3-C7 alkynyl that may be substituted with halogen atom; R2 represents C3-C8 cycloalkyl which may be substituted with C1-C4 alkyl, halogen atom and trifluoromethyl or the like; A1 represents a single bond, C1-C2 alkylene or C2-C3 alkylidene. The 1,2,4-thiadiazole compound has an excellent arthropod controlling activity, and can effectively control an arthropod pests such as insect pests, acarine pests and the like.

  本发明涉及一种新型1,2,4-噻二唑化合物，其化学式表示如下（1）：其中，R1代表可能被卤原子取代的C3-C7炔基；R2代表可能被C1-C4烷基、卤原子和三氟甲基等取代的C3-C8环烷基；A1代表单键、C1-C2烷基或C2-C3烷基。这种1,2,4-噻二唑化合物具有出色的节肢动物控制活性，可以有效控制昆虫害、螨虫害等节肢动物害虫。
• 1,2,4-Thiadiazole compounds and arthropod controlling composition containing the same
  申请人：Ihara Hideki

  公开号：US20060052422A1

  公开（公告）日：2006-03-09

  The present invention relates to a novel 1,2,4-thiadiazole compound represented by the formula (1): wherein, R 1 represents C3-C7 alkynyl that may be substituted with halogen atom; R 2 represents C3-C8 cycloalkyl which may be substituted with C1-C4 alkyl, halogen atom and trifluoromethyl or the like; A 1 represents a single bond, C1-C2 alkylene or C2-C3 alkylidene. The 1,2,4-thiadiazole compound has an excellent arthropod controlling activity, and can effectively control an arthropod pests such as insect pests, acarine pests and the like.

  本发明涉及一种新型1,2,4-噻二唑化合物，其化学式表示为（1）：其中，R1代表可以被卤素原子取代的C3-C7炔基；R2代表可以被C1-C4烷基，卤素原子和三氟甲基等取代的C3-C8环烷基；A1代表单键，C1-C2烷基或C2-C3烷基亚甲基。该1,2,4-噻二唑化合物具有优异的节肢动物控制活性，可以有效地控制昆虫害、螨虫害等节肢动物害虫。
• 2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region
  作者：Shivaji A. Thorat、Dong Wook Kang、HyungChul Ryu、Myeong Seop Kim、Ho Shin Kim、Jihyae Ann、Taehwan Ha、Sung-Eun Kim、Karam Son、Sun Choi、Peter M. Blumberg、Robert Frank、Gregor Bahrenberg、Klaus Schiene、Thomas Christoph、Jeewoo Lee

  DOI：10.1016/j.ejmech.2013.04.003

  日期：2013.6

  The structure activity relationships of 2-oxy pyridine derivatives in the C-region of N-(6-trifluoromethylpyridin-3-ylmethyl) 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as hTRPV1 antagonists were investigated. The analysis indicated that the lipophilicity of the 2-oxy substituents was critical for potent antagonism and 4 or 5 carbons appeared to be optimal for activity. Multiple compounds proved to have comparable activity to 1, which had been reported as the most potent antagonist for capsaicin activity among the previous series of compounds. Further analysis of compounds 22 (2-isobutyloxy) and 53 (2-benzyloxy) in the formalin test in mice demonstrated strong analgesic activity with full efficacy. Docking analysis of 535 using our hTRPV1 homology model indicated that the A- and B-region 2-(3fluoro-4-methylsulfonylaminophenyl)propanamide made important hydrophobic and hydrogen bonding interactions with Tyr511 and that the C-region 6-trifluoromethyl and 2-benzyloxy groups of pyridine occupied the two hydrophobic binding pockets, respectively. (C) 2013 Elsevier Masson SAS. All rights reserved.
• Knoevenagel; Mac Garvey, Justus Liebigs Annalen der Chemie, 1897, vol. 297, p. 162
  作者：Knoevenagel、Mac Garvey

  DOI：——

  日期：——
• 1,2,4-THIADIAZOLE COMPOUNDS AND ARTHROPOD CONTROLLING COMPOSITION CONTAINING THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1569922B1

  公开（公告）日：2009-12-02