tert-Butyl 5-isopropyl-1H-indazole-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: tert-Butyl 5-isopropyl-1H-indazole-1-carboxylate
• 英文别名: tert-butyl 5-propan-2-ylindazole-1-carboxylate
• 化学式: C₁₅H₂₀N₂O₂
• 分子量: 260.33
• InChiKey: XDAUEQRNVHPVMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 2,4-disubstituted pyrimidines useful as kinase inhibitors
  申请人：Celgene CAR LLC

  公开号：US10010548B2

  公开（公告）日：2018-07-03

  The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

  本发明提供了可用作激酶抑制剂的 2,4-二取代嘧啶化合物、其药学上可接受的组合物以及使用方法。
• Substituted 2,4-diaminopyrimidines as kinase inhibitors
  申请人：Celgene CAR LLC

  公开号：US10828300B2

  公开（公告）日：2020-11-10

  The present invention provides 2,4-diaminopyrimidines, and/or pharmaceutically acceptable compositions thereof, as kinase inhibitors.

  本发明提供了作为激酶抑制剂的 2,4-二氨基嘧啶和/或其药学上可接受的组合物。
• RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AS WELL AS PREPARATION METHOD AND USE THEREOF
  申请人：Beijing Tide Pharmaceutical Co., Ltd.

  公开号：EP3421465B1

  公开（公告）日：2022-10-26
• HETEROARYL COMPOUNDS AND USES THEREOF
  申请人：Celgene Avilomics Research, Inc.

  公开号：US20170100397A1

  公开（公告）日：2017-04-13

  The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
• METHOD FOR TREATING FATTY LIVER DISEASE AND/OR STEATOHEPATITIS
  申请人：BEIJING TIDE PHARMACEUTICAL CO., LTD.

  公开号：US20220378743A1

  公开（公告）日：2022-12-01

  The present invention falls within the field of biological medicine, and specifically relates to a method for preventing, alleviating and/or treating fatty liver disease and/or steatohepatitis. The method comprises administering, to an individual in need thereof, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.