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(S)-3-[(R)-1-(naphthalen-1-yl)ethylamino]-1-(3-trifluoromethylbenzoyl)pyrrolidine

中文名称
——
中文别名
——
英文名称
(S)-3-[(R)-1-(naphthalen-1-yl)ethylamino]-1-(3-trifluoromethylbenzoyl)pyrrolidine
英文别名
[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]-[3-(trifluoromethyl)phenyl]methanone
(S)-3-[(R)-1-(naphthalen-1-yl)ethylamino]-1-(3-trifluoromethylbenzoyl)pyrrolidine化学式
CAS
——
化学式
C24H23F3N2O
mdl
——
分子量
412.455
InChiKey
HINNKIOZRGZKED-UZLBHIALSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5.2
  • 重原子数:
    30
  • 可旋转键数:
    4
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.29
  • 拓扑面积:
    32.3
  • 氢给体数:
    1
  • 氢受体数:
    5

反应信息

点击查看最新优质反应信息

文献信息

  • Arylalkylamine Compound and Process for Preparing the Same
    申请人:Miyazaki Hiroshi
    公开号:US20070225296A1
    公开(公告)日:2007-09-27
    The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc. The symbols in the formula represent the following meanings: Ar: optionally substituted aryl or optionally substituted heteroaryl here, the cyclic portion of the heteroaryl is bicyclic heterocyclic ring in which 5- to 6-membered monocyclic heterocyclic ring containing 1 or 2 hetero atom(s) and benzene ring are fused; R 1 : a group selected from the group consisting of optionally substituted cyclic hydrocarbon group, and optionally substituted heterocyclic group; n: an integer of 1 to 3; X: single bonding arm, —CH 2 —, —CO—, —(CH 2 ) m —CO—, —CH(R 2 )—CO—, —(CH 2 ) p —Y—(C(R 3 )(R 4 )) q —CO—, —NH—CO— or —N(R 5 )—CO—; in the above-mentioned respective definitions of the X, the bonding arm described at the left end represents a bond with R 1 ; m is an integer of 1 to 3; p is an integer of 0 to 2; q is an integer of 0 to 2; Y: —O— or —SO 2 —; R 2 : phenyl or lower alkyl; R 3 , R 4 : each independently represents hydrogen atom or lower alkyl; R 5 : lower alkyl; provided that the ring portion of the group represented by R 1 is neither naphthylidine nor partially saturated group thereof, and, when X is —CH 2 — or —CO—, R 1 is not naphthyl.
    本发明涉及一种由以下公式[I]表示的芳基烷基胺化合物或其药学上可接受的盐,其制备方法,以及上述化合物作为钙感受受体的激活化合物(CaSR激动剂),以及含有上述化合物作为有效成分的制药组合物等的用途。公式中的符号表示以下含义:Ar:此处为可选取代的芳基或可选取代的杂环芳基,其中杂环的环部分是一个含有1或2个杂原子的5-至6元单环杂环,与苯环融合;R1:选自可选取代的环烃基团和可选取代的杂环基团的群;n:1至3的整数;X:单键臂、—CH2—、—CO—、—(CH2)m—CO—、—CH(R2)—CO—、—(CH2)p—Y—(C(R3)(R4))q—CO—、—NH—CO—或—N(R5)—CO—;在上述各定义的X中,左端所描述的键臂表示与R1的键;m为1至3的整数;p为0至2的整数;q为0至2的整数;Y:—O—或—SO2—;R2:苯基或低碳烷基;R3、R4:各自独立地表示氢原子或低碳烷基;R5:低碳烷基;前提是由R1表示的基团的环部分既不是萘亚甲基也不是其部分饱和基团,且当X为—CH2—或—CO—时,R1不是萘基。
  • ARYLALKYLAMINE COMPOUND AND PROCESS FOR PREPARING THE SAME
    申请人:MIYAZAKI Hiroshi
    公开号:US20100249049A1
    公开(公告)日:2010-09-30
    The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc. The symbols in the formula represent the following meanings: Ar: optionally substituted aryl or optionally substituted heteroaryl here, the cyclic portion of the heteroaryl is bicyclic heterocyclic ring in which 5- to 6-membered monocyclic heterocyclic ring containing 1 or 2 hetero atom(s) and benzene ring are fused; R 1 : a group selected from the group consisting of optionally substituted cyclic hydrocarbon group, and optionally substituted heterocyclic group; n: an integer of 1 to 3; X: single bonding arm, —CH 2 —, —CO—, —(CH 2 ) m —CO—, —CH(R 2 )—CO—, —(CH 2 ) p —Y—(C(R 3 )(R 4 )) q —CO—, —NH—CO— or —N(R 5 )—CO—; in the above-mentioned respective definitions of the X, the bonding arm described at the left end represents a bond with R 1 ; m is an integer of 1 to 3; p is an integer of 0 to 2; q is an integer of 0 to 2; Y: —O— or —SO 2 —; R 2 : phenyl or lower alkyl; R 3 , R 4 : each independently represents hydrogen atom or lower alkyl; R 5 : lower alkyl; provided that the ring portion of the group represented by R 1 is neither naphthylidine nor partially saturated group thereof, and, when X is —CH 2 — or —CO—, R 1 is not naphthyl.
    本发明涉及一种由下式[I]表示的芳基烷基胺化合物或其药学上可接受的盐,制备该化合物的方法,以及上述化合物作为钙感受受体(CaSR激动剂)的激活化合物、包含上述化合物作为有效成分的药物组合物等的用途。式中符号表示以下含义:Ar:可选取的取代芳基或可选取的取代杂环芳基,在此,所述杂环的环状部分是由1或2个杂原子的5-6元单环杂环与苯环融合而成的双环杂环;R1:选自可选取的取代环烃基团和可选取的取代杂环基团的群;n:为1至3的整数;X:单键连接臂,-CH2-,-CO-,-(CH2)m-CO-,-CH(R2)-CO-,-(CH2)p-Y-(C(R3)(R4))q-CO-,-NH-CO-或-N(R5)-CO-;在上述X的各自定义中,左端所述连接臂表示与R1的键合;m为1至3的整数;p为0至2的整数;q为0至2的整数;Y:-O-或-SO2-;R2:苯基或低碳烷基;R3,R4:各自独立地表示氢原子或低碳烷基;R5:低碳烷基;所述R1表示的基的环部分既不是萘亚甲基基团,也不是其部分饱和基团,当X为-CH2-或-CO-时,R1不是萘基。
  • US8362274B2
    申请人:——
    公开号:US8362274B2
    公开(公告)日:2013-01-29
  • US8492111B2
    申请人:——
    公开号:US8492111B2
    公开(公告)日:2013-07-23
  • US8703721B2
    申请人:——
    公开号:US8703721B2
    公开(公告)日:2014-04-22
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