1-hydroxy-naphthalene-2-carboxylic acid (4-cyano-2-trifluoromethoxy-phenyl)-amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-hydroxy-naphthalene-2-carboxylic acid (4-cyano-2-trifluoromethoxy-phenyl)-amide
• 英文别名: 1-Hydroxy-naphthalene-2-carboxylic acid(4-cyano-2-trifluoromethoxy-phenyl)-amide；N-[4-cyano-2-(trifluoromethoxy)phenyl]-1-hydroxynaphthalene-2-carboxamide
• 化学式: C₁₉H₁₁F₃N₂O₃
• 分子量: 372.303
• InChiKey: CHLSBURWRMTBJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-氨基-3-三氟甲氧基苯腈 、 1-羟基-2-萘甲酸 生成 1-hydroxy-naphthalene-2-carboxylic acid (4-cyano-2-trifluoromethoxy-phenyl)-amide
  参考文献：
  名称：

  Novel Trifluoromethoxy-Substituted Aryl Anilides

  摘要：

  本发明涉及一种新型化合物，其作为化学解偶联剂。该发明的化合物在治疗肥胖症、糖尿病以及与之相关的多种疾病或疾病的预防中是有用的。

  公开号：

  US20080234381A1

文献信息

• WO2006/125778
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] NICOTINYL RIBOSIDE COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS NICOTINYL RIBOSIDE ET LEURS UTILISATIONS
  申请人：MITOPOWER LLC

  公开号：WO2020257283A1

  公开（公告）日：2020-12-24

  The disclosure provides nicotinamide riboside (NR), the reduced form of NR (NRH), nicotinic acid riboside (NAR), the reduced form of NAR (NARH), derivatives thereof, compositions thereof and uses thereof. The NR and NAR derivatives have improved stability and bioavailability compared to NR and NAR. NR, NRH, NAR, NARH, and derivatives thereof can increase cellular NAD+ levels and enhance mitochondrial and cellular function and cell viability. Therefore, NR, NRH, NAR, NARH, and derivatives thereof, whether alone or in combination with one or more additional therapeutic agents (e.g., a mitochondrial uncoupler or/and a PARP inhibitor), are useful for treating mitochondrial diseases, mitochondria-related diseases and conditions, metabolic disorders, and other disorders and conditions.
• Novel Trifluoromethoxy-Substituted Aryl Anilides
  申请人：Olesen Preben Houlberg

  公开号：US20080234381A1

  公开（公告）日：2008-09-25

  The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or disorders associated therewith.

  本发明涉及一种新型化合物，其作为化学解偶联剂。该发明的化合物在治疗肥胖症、糖尿病以及与之相关的多种疾病或疾病的预防中是有用的。