1-hydroxy-N-piperidin-4-yl-2-naphthamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-hydroxy-N-piperidin-4-yl-2-naphthamide
• 英文别名: 1-hydroxy-N-(piperidin-4-yl)naphthalene-2-carboxamide；1-hydroxy-N-piperidin-4-ylnaphthalene-2-carboxamide
• 化学式: C₁₆H₁₈N₂O₂
• 分子量: 270.331
• InChiKey: OQBCIEBPJYIQIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyl 4-[(1-hydroxy-2-naphthoyl)amino]piperidine-1-carboxylate 在 盐酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 以89.67 %的产率得到1-hydroxy-N-piperidin-4-yl-2-naphthamide
  参考文献：
  名称：

  [EN] SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES
  [FR] RÉGULATEURS À PETITES MOLÉCULES DE LA PROLIFÉRATION DES CELLULES ALVÉOLAIRES DE TYPE 2 POUR LE TRAITEMENT DE MALADIES PULMONAIRES

  摘要：

  The present disclosure relates to compounds, and to their pharmaceutical compositions, that inhibit dipeptidyl peptidase IV (DPP4). The compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology, for example, derives from epithelial degeneration and maladaptive remodeling, such as pulmonary diseases like idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), and infant respiratory distress syndromes (IRDS).

  公开号：

  WO2024015889A2

文献信息

• [EN] SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES<br/>[FR] RÉGULATEURS À PETITES MOLÉCULES DE LA PROLIFÉRATION DES CELLULES ALVÉOLAIRES DE TYPE 2 POUR LE TRAITEMENT DE MALADIES PULMONAIRES
  申请人：[en]THE SCRIPPS RESEARCH INSTITUTE

  公开号：WO2024015889A2

  公开（公告）日：2024-01-18

  The present disclosure relates to compounds, and to their pharmaceutical compositions, that inhibit dipeptidyl peptidase IV (DPP4). The compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology, for example, derives from epithelial degeneration and maladaptive remodeling, such as pulmonary diseases like idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), and infant respiratory distress syndromes (IRDS).
• Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation
  作者：Sabrina Aït Amiri、Cyrille Deboux、Feryel Soualmia、Nancy Chaaya、Maxime Louet、Eric Duplus、Sandrine Betuing、Brahim Nait Oumesmar、Nicolas Masurier、Chahrazade El Amri

  DOI：10.1021/acs.jmedchem.0c02175

  日期：2021.5.13