12-mercaptododecanoic-(8-biotinoylamido-3,6-dioxaoctyl) amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 12-mercaptododecanoic-(8-biotinoylamido-3,6-dioxaoctyl) amide
• 英文别名: 12-mercaptododecanoic-(8-biotinoylamido-3,6-dioxaoctyl)amide；N-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethyl]-12-sulfanyldodecanamide
• 化学式: C₂₈H₅₂N₄O₅S₂
• 分子量: 588.877
• InChiKey: KZZZBCRCXRNOTE-DPZBCOQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  39
• 可旋转键数：
  25
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  144
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (+)生物素-N-琥珀酰亚胺基酯 在 氨 、 sodium 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 12-mercaptododecanoic-(8-biotinoylamido-3,6-dioxaoctyl) amide
  参考文献：
  名称：

  Synthesis of novel biotin anchors

  摘要：

  Details are reported of the synthesis of biotinylated thiol and cholesteryl derivatives. The biotin derivative has been used to form multilayer films on gold through interaction with streptavidin. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01003-1

文献信息

• US6277489B1
  申请人：——

  公开号：US6277489B1

  公开（公告）日：2001-08-21
• [EN] A NEW SUPPORT FOR HIGH PERFORMANCE AFFINITY CHROMATOGRAPHY AND OTHER USES<br/>[FR] NOUVEAU SUPPORT DESTINE A LA CHROMATOGRAPHIE PAR AFFINITE A HAUTE PERFORMANCE ET AUTRES UTILISATIONS
  申请人：UNIV CALIFORNIA

  公开号：WO2000032044A1

  公开（公告）日：2000-06-08

  Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moiety can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel particulate materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis, as supports in solid phase synthesis, combinatorial synthesis and screening of compound libraries and the like.
• Synthesis of novel biotin anchors
  作者：Claire Booth、Richard J Bushby、Yaling Cheng、Stephen D Evans、Quanying Liu、Haoli Zhang

  DOI：10.1016/s0040-4020(01)01003-1

  日期：2001.12

  Details are reported of the synthesis of biotinylated thiol and cholesteryl derivatives. The biotin derivative has been used to form multilayer films on gold through interaction with streptavidin. (C) 2001 Elsevier Science Ltd. All rights reserved.