2,2-dimethyl-7-(2-dimethylaminoethoxy)-4(6-methoxy-2-naphthyl)-2H-chromene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2-dimethyl-7-(2-dimethylaminoethoxy)-4(6-methoxy-2-naphthyl)-2H-chromene
• 英文别名: 2,2-Dimethyl-7-(2-dimethylaminoethoxy)-4(6-methoxy-2-naphthyl)2H-chromene；2-[4-(6-methoxynaphthalen-2-yl)-2,2-dimethylchromen-7-yl]oxy-N,N-dimethylethanamine
• 化学式: C₂₆H₂₉NO₃
• 分子量: 403.521
• InChiKey: QUYBTVOGKRECIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-7-hydroxy-4(6-methoxy-2-naphthyl)-2H-chromene 、 2-氯-N,N-二甲基乙胺 以 水 、 甲苯 为溶剂， 生成 2,2-dimethyl-7-(2-dimethylaminoethoxy)-4(6-methoxy-2-naphthyl)-2H-chromene
  参考文献：
  名称：

  Anorexic chromans

  摘要：

  在化学式##STR1##中的化合物及其盐，其中X是2-4个碳原子的烷基；R.sub.1是氢或1-6个碳原子的烷基；R.sub.2是氢，1-6个碳原子的烷基或苄基，或者R.sub.1和R.sub.2与它们连接的氮原子一起形成一个5、6或7元饱和环；R.sub.3是芳基；R.sub.4是氢或1-4个碳原子的烷基；R.sub.5是氢或1-4个碳原子的烷基；已发现具有改变情绪和诱导厌食的活性。

  公开号：

  US04080335A1

文献信息

• Anorexic chromans
  申请人：Beecham Group Limited

  公开号：US04080335A1

  公开（公告）日：1978-03-21

  Compounds within formula ##STR1## and their salts wherein X is alkylene of 2 - 4 carbon atoms; R.sub.1 is hydrogen or alkyl of 1 - 6 carbon atoms; R.sub.2 is hydrogen, alkyl of 1 - 6 carbon atoms or benzyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered saturated ring; R.sub.3 is aryl; R.sub.4 is hydrogen or alkyl of 1 - 4 carbon atoms; and R.sub.5 is hydrogen or alkyl of 1 - 4 carbon atoms; have been found to possess mood-modifying and anorexia inducing activity.

  在化学式##STR1##中的化合物及其盐，其中X是2-4个碳原子的烷基；R.sub.1是氢或1-6个碳原子的烷基；R.sub.2是氢，1-6个碳原子的烷基或苄基，或者R.sub.1和R.sub.2与它们连接的氮原子一起形成一个5、6或7元饱和环；R.sub.3是芳基；R.sub.4是氢或1-4个碳原子的烷基；R.sub.5是氢或1-4个碳原子的烷基；已发现具有改变情绪和诱导厌食的活性。
• 4-Naphthyl derivatives of 7-aminoalkylenoxy-2H-chromene
  申请人：Beecham Group Limited

  公开号：US04079066A1

  公开（公告）日：1978-03-14

  Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein X is an alkylene group of 2 - 4 carbon atoms; Y is CH.sub.2 or 0; R.sub.1 is a hydrogen atom or a C.sub.1-6 alkyl group; R.sub.2 is a hydrogen atom or a C.sub.1-6 alkyl or benzyl group or is joined to R.sub.1 so that NR.sub.1 R.sub.1 is a 5-, 6- or 7- membered saturated ring; R.sub.3 is a naphthyl group or a naphthyl group substituted by a fluorine, chlorine or bromine atom or a methyl, methoxyl, trifluoromethyl, hydroxy or acetoxy group; R.sub.4 is a hydrogen atom or a C.sub.1-4 alkyl group; and R.sub.5 is a hydrogen atom or a C.sub.1-4 alkyl group; have been found to be mood modifying agents.

  配方(I)的化合物：其中X是2-4个碳原子的烷基基团；Y是CH.sub.2或0；R.sub.1是氢原子或C.sub.1-6烷基基团；R.sub.2是氢原子或C.sub.1-6烷基或苄基团，或与R.sub.1结合使得NR.sub.1 R.sub.1是5、6或7-成员饱和环；R.sub.3是萘基或被氟、氯或溴原子取代的萘基或甲基、甲氧基、三氟甲基、羟基或乙酰氧基基团；R.sub.4是氢原子或C.sub.1-4烷基基团；R.sub.5是氢原子或C.sub.1-4烷基基团；已被发现是调节情绪的药物。
• Chromans to treat depression and reduce appetite
  申请人：Beecham Group Limited

  公开号：US04148909A1

  公开（公告）日：1979-04-10

  Compounds within formula ##STR1## and their salts wherein X is alkylene of 2-4 carbon atoms; R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms; R.sub.2 is hydrogen, alkyl of 1-6 carbon atoms or benzyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered saturated ring; R.sub.3 is aryl; R.sub.4 is hydrogen or alkyl of 1-4 carbon atoms; and R.sub.5 is hydrogen or alkyl of 1-4 carbon atoms; have been found to possess mood-modifying and anorexia inducing activity.

  在式子##STR1##内和它们的盐中，其中X是2-4个碳原子的烷基；R.sub.1是氢或1-6个碳原子的烷基；R.sub.2是氢、1-6个碳原子的烷基或苄基，或者R.sub.1和R.sub.2与它们连接的氮原子一起形成一个5、6或7元饱和环；R.sub.3是芳基；R.sub.4是氢或1-4个碳原子的烷基；R.sub.5是氢或1-4个碳原子的烷基。已发现这些化合物具有调节情绪和引起厌食的活性。
• Anemone plant named ‘Curtain Call Pink’
  申请人：Hansen Hans A

  公开号：USPP030739P2

  公开（公告）日：2019-07-23

  The new and distinct cultivar of ornamental Japanese Anemone plant named Anemone ‘Curtain Call Pink’ with compact spreading habit, vertical peduncle of numerous semi-double flowers with bright rose pink petals, beginning late summer and continuing into early fall, set just above the dark green, tri-foliate leaves with irregularly serrated to bi-serrated. The new plant is useful for landscaping as a specimen, en masse, or in containers.

  这是一种新的、独特的观赏日本银莲花植物品种，名为“Anemone‘Curtain Call Pink’”。它具有紧凑的扩散习性，垂直的花茎上有众多的半重瓣花朵，花瓣呈鲜艳的玫瑰粉色，开花时间从夏末延续到初秋，花朵位于深绿色的三出叶片上，叶缘呈不规则锯齿状或双锯齿状。这种新植物可用于景观设计中的单株、群植或容器中。
• US4080335A
  申请人：——

  公开号：US4080335A

  公开（公告）日：1978-03-21