N-(4-methyl-1,3-thiazol-2-yl)-1H-indazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: N-(4-methyl-1,3-thiazol-2-yl)-1H-indazole-3-carboxamide
• 化学式: C₁₂H₁₀N₄OS
• mdl: MFCD21370926
• 分子量: 258.3
• InChiKey: HODWOYIBJBYZHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  98.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• N-(1-thiazolyl)-amide derivatives for the treatment of obesity, diabetes and cardiovascular diseases
  申请人：Zeltia, S.A.

  公开号：EP2020232A1

  公开（公告）日：2009-02-04

  The invention relates to the use of a compound of formula (I) : its pharmaceutically acceptable salts, prodrugs and/or solvates, in the preparation of a medicinal product for the treatment of a disease presenting altered adiponectin levels or in which it is necessary to alter the adiponectin protein levels.

  该发明涉及使用以下化合物的药用盐、前药和/或溶剂化物，用于制备治疗疾病的药物产品，该疾病表现出改变的脂联素水平或需要改变脂联素蛋白水平。
• N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES
  申请人：Martínez Gil Ana

  公开号：US20110213000A1

  公开（公告）日：2011-09-01

  The invention relates to the use of a compound of formula (I): its pharmaceutically acceptable salts, prodrugs and/or solvates, in the preparation of a medicinal product for the treatment of a disease presenting altered adiponectin levels or in which it is necessary to alter the adiponectin protein levels.

  本发明涉及使用式(I)的化合物，其药学上可接受的盐、前药和/或溶剂，用于制备治疗存在改变脂联素水平或需要改变脂联素蛋白水平的疾病的药物产品。
• [EN] N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES<br/>[FR] DÉRIVÉS DE N-(2-THIAZOLYL)-AMIDE POUR LE TRAITEMENT DE L'OBÉSITÉ, DU DIABÈTE ET DE MALADIES CARDIOVASCULAIRES
  申请人：ZELTIA S A

  公开号：WO2009019202A1

  公开（公告）日：2009-02-12

  The invention relates to the use of a compound of formula (I): its pharmaceutically acceptable salts, prodrugs and/or solvates, in the preparation of a medicinal product for the treatment of a disease presenting altered adiponectin levels or in which it is necessary to alter the adiponectin protein levels.