triphenyl-acetic acid butyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: triphenyl-acetic acid butyl ester
• 英文别名: Triphenyl-essigsaeure-butylester；Butyl 2,2,2-triphenylacetate
• 化学式: C₂₄H₂₄O₂
• 分子量: 344.453
• InChiKey: TWPFZPXGZCWYQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三苯基乙酸 在 氯化亚砜 作用下， 生成 triphenyl-acetic acid butyl ester
  参考文献：
  名称：

  The Reactivity of Atoms and Groups in Organic Compounds. XIII. The Influence of Structure on the Pyrolysis of Esters of Triphenylacetic Acid¹

  摘要：

  DOI：

  10.1021/ja01317a043

文献信息

• Laminated structure having post-chlorinated adhesive olefin resin layer
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0149356B1

  公开（公告）日：1988-09-07
• Crystalline 1-butene polymer composition
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0171976B1

  公开（公告）日：1989-10-18
• [EN] BISINDOLES FOR TREATING PAIN OR NOCICEPTION<br/>[FR] BINSINDOLES POUR TRAITER LA DOULEUR OU LES PHENOMENES NOCICEPTIFS
  申请人：ELI LILLY AND COMPANY

  公开号：WO1997038692A1

  公开（公告）日：1997-10-23

  (EN) This invention provides a series of bisindoles having activity as both a tachykinin receptor antagonist and a serotonin agonist. This invention provides methods of using these bisindoles to treat migraine, pain or nociception, allergic rhinitis, the common cold, and a variety of psychiatric disorders.(FR) L'invention porte sur une série de bisindoles agissant à la fois comme antagonistes des récepteurs de tachikinine et comme agonistes de la sérotonine. Elle propose des méthodes d'utilisation de ces bisindoles dans le traitement des douleurs et des phénomènes nociceptifs liés à la migraine, aux rhinites allergiques, aux rhinites banales ainsi que dans le traitement d'une variété de troubles psychiatriques.
• [EN] STYRENIC GRAFT COPOLYMER AND METHOD OF PREPARING THE SAME<br/>[FR] COPOLYMERE GREFFE STYRENE ET SON PROCEDE DE PREPARATION
  申请人：SAMSUNG ELECTRONICS CO LTD

  公开号：WO2000053649A1

  公开（公告）日：2000-09-14

  A styrenic grafted copolymer is disclosed, in which one or more monomers with ethylenically unsaturated bonds are grafted to a syndiotactic polystyrene. The styrenic grafted copolymer is produced through the following steps: (1) preparing a syndiotactic stereogular styrenic polymer having repeating units (A) by polymerizing vinyl aromatic monomers under a catalyst system, the catalyst system consisting of transition metal compounds (I) as main catalyst components and organic aluminum compounds or aluminoxanes (II) as cocatalyst components; and (2) graft-polymerizing monomers of formula (B) having ethylenically unsaturated bonds to the syndiotactic stereoregular styrenic polymer: where R1 is hydrogen, halogen, or a substituent not containing carbon-carbon double bonds but containing one or more components selected from the group consisting of: carbon, oxygen, nitrogen, sulfur, phosphorus, selenium, silicon, and tin; and m is an integer from 1 to 3 (if m is 2 or 3, R1 is same or different); where each of R2-R5 is hydrogen, halogen, or a substituent containing one or more components selected from the group consisting of: carbon, oxygen, nitrogen, sulfur, phosphorus, selenium, silicon, and tin.
• [EN] COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING NOVEL DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME<br/>[FR] COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES LIÉES AU TNF, CONTENANT UN NOUVEAU DÉRIVÉ EN TANT QUE PRINCIPE ACTIF, ET PROCÉDÉ D'INHIBITION DE L'ACTIVITÉ DU TNF À L'AIDE DE CELLE-CI<br/>[KO] 신규한 유도체를 유효성분으로 포함하는 TNF-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 TNF 활성 억제 방법
  申请人：CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION

  公开号：WO2019078452A1

  公开（公告）日：2019-04-25

  본 발명은 4-벤조피라논 유도체, 이의 약학적으로 허용 가능한 염, 용매화물, 라세미체 또는 입체이성질체, 이를 유효성분으로 포함하는 TNF-관련 질환 예방, 개선, 치료용 조성물, 이를 이용한 TNF-관련 질환 치료 방법, TNF 억제용 시약 조성물 및 TNF 억제 방법에 관한 것으로, 상기 조성물들은 경구 투여가 가능하므로 주사 부작용이 없고, 면역원성 내성 발생도 없으며, 종래의 경구제제들과의 병용 투여 및 용량 조절이 용이하면서도, TNF에 직접 결합하여 TNF 활성을 효과적으로 억제할 수 있다.