dimethyl 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: dimethyl 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate
• 英文别名: methyl 7-methoxy-6-(2,3,4-trimethoxy-6-methoxycarbonylphenyl)-1,3-benzodioxole-5-carboxylate
• 化学式: C₂₁H₂₂O₁₀
• 分子量: 434.4
• InChiKey: LFLWJOGKTBJEKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  dimethyl 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate 、 、 sodium hydroxide 在 甲醇 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以to obtain 1.3 g of 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1' -biphenyl-6,6'-dicarboxylic acid (the yield was 81%)的产率得到2,2',3,4-Tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylic acid
  参考文献：
  名称：

  Biphenyl derivative and production and use thereof

  摘要：

  本发明涉及一种具有调节肝脏疾病作用的新型联苯衍生物，该联苯衍生物可用于治疗急性肝炎和慢性肝炎等肝脏疾病，还涉及一种制备该衍生物的方法和以该衍生物为活性成分的调节肝脏疾病的药剂。此外，本发明还涉及一种有价值的中间化合物，用于合成该衍生物的过程以及高效制备该中间化合物的方法。

  公开号：

  US05032685A1
• 作为产物：
  描述：

  lead(IV) tetraacetate 、 硫酸二甲酯 、 dimethyl 4,4'-dimethoxy-[5,5']bi[1,3-benzodioxolyl]-6,6'-dicarboxylate 在 potassium carbonate 、 溶剂黄146 作用下， 生成 dimethyl (S)-4,4',5,5',6,6'-hexamethoxydiphenoate 、 dimethyl 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate
  参考文献：
  名称：

  Monoacetoxylation of Methylenedioxy Groups in Dimethyl 4,4'-Dimethoxy-2,3,2',3'-bismethylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate with Lead Tetraacetate

  摘要：

  The utility of lead tetraacetate as a reagent for the monoacetoxylation of a methylenedioxy group in dimethyl 4,4'-dimethoxy-2,3,2'3'-bismeth-ylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate (1a) is demonstrated. Mechanistic feature of the monoacetoxylation is discussed.

  DOI：

  10.3987/com-92-6323

文献信息

• Biphenyl derivative useful in the treatment of liver diseases
  申请人：Tsumura & Co.

  公开号：US04904694A1

  公开（公告）日：1990-02-27

  The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.

  本发明涉及一种具有调节肝病作用的新型联苯衍生物，可用于治疗急性肝炎和慢性肝炎等肝脏疾病，以及制备该衍生物的方法和以该衍生物为活性成分的肝病调节剂。此外，本发明还涉及一种作为合成该衍生物的中间化合物有价值的化合物和一种高效制备该中间化合物的方法。
• Novel biphenyl derivative and production and use thereof
  申请人：Tsumura & Co.

  公开号：US04987240A1

  公开（公告）日：1991-01-22

  The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.

  本发明涉及一种具有调节肝病作用的新型联苯衍生物，其对于治疗急性肝炎和慢性肝炎等肝病有效，以及制备该衍生物的方法和以该衍生物为活性成分的调节肝病剂。此外，本发明还涉及一种有价值的中间化合物，用于合成该衍生物，以及一种高效制备该中间化合物的方法。
• NOVEL BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE
  申请人：TSUMURA & CO.

  公开号：EP0269754A1

  公开（公告）日：1988-06-08

  Biphenyl derivatives represented by formula (I), process for their preparation, liver trouble-relieving agents containing the derivatives as effective ingredients, and intermediates represented by formula (II) for preparing the derivatives. The compounds of the formula (I) are prepared by reacting an alkyl gallate with a methylating agent, halogenating the product, mono-dehalogenating the product to prepare the intermediate (II), methylating it, coupling the product according to the Ullmann reaction, and reacting the product with lead tetraacetate, wherein R, and R2 each represents H or CH3, and X represents a halogen atom.

  由式(I)表示的联苯衍生物，其制备工艺，含有该衍生物作为有效成分的肝脏问题缓解剂，以及由式(II)表示的用于制备该衍生物的中间体。式(I)化合物的制备方法是：将没食子酸烷基酯与甲基化剂反应，卤化产物，单脱卤制备中间体(II)，将其甲基化，根据乌尔曼反应偶联产物，并使产物与四乙酸铅反应，其中R和R2分别代表H或CH3，X代表卤素原子。
• US4904694A
  申请人：——

  公开号：US4904694A

  公开（公告）日：1990-02-27
• US4962211A
  申请人：——

  公开号：US4962211A

  公开（公告）日：1990-10-09