dansyl-(R)-threonine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dansyl-(R)-threonine
• 英文别名: (2R,3R)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-hydroxybutanoic acid
• 化学式: C₁₆H₂₀N₂O₅S
• 分子量: 352.411
• InChiKey: FKKZRYVWMJRWNI-MEBBXXQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  dansyl-D,L-threonine 在 6^A-4-hydroxyethyl-1,2,3-triazole-6^C-3-methoxypropylimidazolium-β-cyclodextrin chloride 作用下， 以 aq. phosphate buffer 为溶剂， 生成 dansyl-(R)-threonine 、 (2S,3R)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-hydroxy-butyric acid
  参考文献：
  名称：

  Clicked AC regioisomer cationic cyclodextrins for enantioseparation

  摘要：

  通过叠氮/炔点击化学，成功制备了一系列新型AC区域异构阳离子环糊精。这些点击合成的环糊精被探索用于毛细管电泳中酸性消旋体的对映体拆分。

  DOI：

  10.1039/c4ra06279e

文献信息

• Termination of the structural confusion between plipastatin A1 and fengycin IX
  作者：Miho Honma、Kazuaki Tanaka、Katsuhiro Konno、Kenji Tsuge、Toshikatsu Okuno、Masaru Hashimoto

  DOI：10.1016/j.bmc.2012.04.040

  日期：2012.6

  Plipastatin A1 and fengycin IX were experimentally proven to be identical compounds, while these had been considered as diastereomers due to the permutation of the enantiomeric pair of Tyr in most papers. The H-1 NMR spectrum changed to become quite similar to that of plipastatin A1, when the sample which provided resembled spectrum of fengycin IX was treated with KOAc followed by LH-20 gel filtration. Our structural investigations disclosed that the structures of these molecules should be settled into that of plipastatin A1 by Umezawa (L-Tyr4 and D-Tyr10). (C) 2012 Elsevier Ltd. All rights reserved.
• Clicked AC regioisomer cationic cyclodextrins for enantioseparation
  作者：Jie Zhou、Yun Liu、Yingying Lu、Jian Tang、Weihua Tang

  DOI：10.1039/c4ra06279e

  日期：——

  Novel AC regioisomer cationic cyclodextrins have been successfully prepared with azide/alkyne click chemistry. The clicked CDs were explored for the enantioseparation of acidic racemates in capillary electrophoresis.

  通过叠氮/炔点击化学，成功制备了一系列新型AC区域异构阳离子环糊精。这些点击合成的环糊精被探索用于毛细管电泳中酸性消旋体的对映体拆分。