壬基三氯化硅烷 | 5283-67-0

• 物质功能分类: 化学试剂 - 有机试剂 - 硅烷
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 壬基三氯化硅烷
• 中文别名: 壬基三氯硅烷
• 英文名称: trichloro-nonyl-silane
• 英文别名: Trichlor-nonyl-silan；n-Nonyltrichlorsilan；Nonyltrichlorosilane；trichloro(nonyl)silane
• CAS: 5283-67-0
• 化学式: C₉H₁₉Cl₃Si
• 分子量: 261.694
• InChiKey: SSBOTKQTCWQWMG-UHFFFAOYSA-N

物化性质

• 沸点：
  75.7°C
• 密度：
  1.072 g/cm3(Temp: 25 °C)
• 物理描述：
  Nonyltrichlorosilane is a colorless liquid with a pungent odor. It is decomposed by water to hydrochloric acid with evolution of heat. It is corrosive to metals and tissue.
• 颜色/状态：
  Water-white liquid
• 气味：
  Pungent irritating odor
• 稳定性/保质期：
  Fumes readily in moist air.
• 分解：
  The silanes decomp at elevated temp to liberate hydrogen and deposit a high purity silicon, which leads to some of the principal uses of silanes. /Silanes/
• 腐蚀性：
  Corrosive

计算性质

• 辛醇/水分配系数(LogP)：
  5.39
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

氯硅烷在与组织液接触时，会迅速水解释放氯化氢。

... Chlorosilanes will be rapidly hydrolyzed upon contact with tissue fluids to release hydrochloric acid. /Chlorosilanes/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

Dermatotoxin - 皮肤烧伤。

Dermatotoxin - Skin burns.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

立即急救：确保已经进行了充分的中和。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、袋阀面罩装置或口袋面罩，按训练进行操作。根据需要执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者发生呕吐，让患者向前倾或将其置于左侧（如果可能的话，头部向下），以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。/硅烷、氯硅烷及其相关化合物/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道（如需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非重复呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……。预期可能出现癫痫，并在必要时进行治疗……。监测休克，并在必要时进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能够吞咽、有强烈的呕吐反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭（参阅第三部分的摄入协议……）。在去污后，用无菌敷料覆盖皮肤烧伤……。/硅烷、氯硅烷及其相关化合物/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。在上呼吸道阻塞的第一个迹象出现时，可能需要早期插管。使用气囊面罩的积极压力通气技术可能有益。考虑对肺水肿进行药物治疗...。监测心率和必要时治疗心律失常...。开始静脉输注D5W/SRP：“保持开放”，最低流速/。如果出现低血容量的迹象，使用0.9%盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量症状的低血压，谨慎给予液体。如果病人在正常液体容量下出现低血压，考虑使用血管加压药。注意液体过载的迹象...。用地西泮或劳拉西泮治疗癫痫...。使用丙美卡因氢氯化物协助眼部冲洗...。/硅烷、氯硅烷及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

体征和症状/ 急性吸入暴露可能会导致打喷嚏、窒息、喉炎、呼吸困难（气短）、呼吸道刺激和胸痛。更高剂量的暴露可能会导致肺水肿，这是一种可以延迟数小时的医疗紧急情况。这可能会导致死亡。鼻子和牙龈出血、鼻和口腔粘膜溃疡、肺水肿、慢性支气管炎和肺炎也可能发生。如果眼睛接触到二甲二氯硅烷，可能会导致刺激、疼痛、肿胀、角膜侵蚀和失明。皮炎（红色、发炎的皮肤）、严重烧伤、疼痛和休克通常会在皮肤暴露后发生。吸入刺激粘膜。可能会发生严重的胃肠损伤。蒸汽会导致严重的眼睛和肺部伤害。在短暂的接触后，可能会发生二度和三度烧伤。二甲二氯硅烷的急性摄入的体征和症状可能是严重的，包括唾液分泌增加、强烈的口渴、吞咽困难、寒战、疼痛和休克。口腔、食管和胃烧伤很常见。/二甲二氯硅烷/

/SIGNS AND SYMPTOMS/ Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Higher exposure can cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with dimethyldichlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure. Inhalation irritates mucous membranes. Severe gastrointestinal damage may occur. Vapors cause severe eye and lung injury. Upon short contact, second and third degree burns may occur. Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. /Dimethyldichlorosilane/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  8
• 危险品运输编号：
  UN 1799
• 海关编码：
  2931900090
• 包装等级：
  II

SDS

第一部分：化学品名称

制备方法与用途

类别：腐蚀物品

可燃性危险特性：

• 易燃
• 遇水放出有毒氯化氢气体
• 火中放出有毒气体

储运特性：

• 应存放在库房内，保持通风、低温和干燥环境
• 与碱类、氧化剂及酸分开存放

灭火剂：

• 干粉
• 二氧化碳

反应信息

• 作为反应物：
  描述：

  壬基三氯化硅烷 在 氨 作用下， 生成 Hexa-n-nonylsilsesquiazan
  参考文献：
  名称：

  Synthesis and properties of organocyclosilazanes

  摘要：

  DOI：

  10.1016/s0022-328x(00)91070-2
• 作为产物：
  描述：

  壬烯 在 三氯硅烷 作用下， 生成 壬基三氯化硅烷
  参考文献：
  名称：

  Toptschiew et al., Doklady Akademii Nauk SSSR, 1957, vol. 115, p. 326,328

  摘要：

  DOI：

文献信息

• Andrianov,K.A.; Izmailov,B.A., Journal of general chemistry of the USSR, 1965, vol. 35, # 6, p. 1045 - 1048
  作者：Andrianov,K.A.、Izmailov,B.A.

  DOI：——

  日期：——
• Nametkin et al., Doklady Akademii Nauk SSSR, 1959, vol. 126, p. 794,797
  作者：Nametkin et al.

  DOI：——

  日期：——
• Nucleophilic reactions of organocyclosilazanes of different structure
  作者：K.A. Andrianov、G.V. Kotrelev、B.A. Kamaritski、I.H. Unitski、N.I. Sidorova

  DOI：10.1016/s0022-328x(00)81635-6

  日期：1969.1
• Toptschiew et al., Doklady Akademii Nauk SSSR, 1957, vol. 115, p. 326,328
  作者：Toptschiew et al.

  DOI：——

  日期：——
• Nametkin et al., Doklady Akademii Nauk SSSR, 1959, vol. 126, p. 1001
  作者：Nametkin et al.

  DOI：——

  日期：——