1-(2,4-Dihydroxy-6-methylphenyl)-2-quinolin-8-ylethanone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(2,4-Dihydroxy-6-methylphenyl)-2-quinolin-8-ylethanone
• 化学式: C₁₈H₁₅NO₃
• 分子量: 293.3
• InChiKey: NXCNONSKOCTXNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NADPH oxidase inhibitors and uses thereof
  申请人：Emory University

  公开号：US11236053B2

  公开（公告）日：2022-02-01

  This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

  本公开涉及治疗或预防与Nox相关的疾病或病症的化合物和方法，包括向有需要的受试者施用Nox抑制剂或药物组合物，其中包含本文公开的Nox抑制剂、衍生物或本文公开的化合物，可任选被一种或多种替代物取代，包括任选的盐和原药形式。在某些实施方案中，本公开涉及本文所报道的磺酰脲化合物及其用途。
• NADPH Oxidase Inhibitors and Uses Thereof
  申请人：Emory University

  公开号：US20200270214A1

  公开（公告）日：2020-08-27

  This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.