4-hydroxyphenethyl heptacosanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-hydroxyphenethyl heptacosanoate
• 英文别名: 4-hydroxyphenethyl carbocerate
• 化学式: C₃₅H₆₂O₃
• 分子量: 530.875
• InChiKey: FTASQXDVGIJHLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.25
• 重原子数：
  38.0
• 可旋转键数：
  28.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-hydroxyphenethyl heptacosanoate 在 水 作用下， 生成 二十七烷酸 、 对羟基苯乙醇
  参考文献：
  名称：

  Chemical constituents with antimicrobial and antioxidant activity from the aerial parts of Callistemon lanceolatus (Sm.) Sweet

  摘要：

  Callistemon lanceolatus (Sm.) Sweet grows all over the world and used to treat cough and bronchitis. The air-dried powder of the aerial parts was exhaustively extracted with methanol and the concentrated extract was adsorbed on silica gel for preparation of slurry. It was dried and subjected to silica gel column packed in petroleum ether. The column was eluted with organic solvents in order of increasing polarity to isolate 1-triacosanol (1), n-eicosanyl palmitate (2), n-heptadecanyl arachidate (3), n-tricosanyl palmitate, (4), 4-hydroxyphenethyl carbocerate (5), 4-hydroxyphenethyl gheddate (6), urs-12-en-3 alpha-acetoxy-18 beta-H-28-oic acid (7) and stigmast-5-en-3 beta-ol-3 beta-D-glucuronopyranoside (8). Among them, compound 5 and 6 were new fatty acid ester isolated from this plant. Compound 7 showed MIC 32 mu g/mL against E. coli which was comparable to amoxicillin having same MIC 32 mu g/mL. Compound 5 and 6 showed significant antioxidant activity by inhibiting DPPH due to the presence of phenolic groups.

  DOI：

  10.1080/14786419.2018.1557174

文献信息

• Chemical constituents with antimicrobial and antioxidant activity from the aerial parts of <i>Callistemon lanceolatus</i> (Sm.) Sweet
  作者：Syed Nazreen、Mohammad Mahboob Alam、Hinna Hamid、Mohammad Ali、Mohammad Sarwar Alam

  DOI：10.1080/14786419.2018.1557174

  日期：2020.11.16

  Callistemon lanceolatus (Sm.) Sweet grows all over the world and used to treat cough and bronchitis. The air-dried powder of the aerial parts was exhaustively extracted with methanol and the concentrated extract was adsorbed on silica gel for preparation of slurry. It was dried and subjected to silica gel column packed in petroleum ether. The column was eluted with organic solvents in order of increasing polarity to isolate 1-triacosanol (1), n-eicosanyl palmitate (2), n-heptadecanyl arachidate (3), n-tricosanyl palmitate, (4), 4-hydroxyphenethyl carbocerate (5), 4-hydroxyphenethyl gheddate (6), urs-12-en-3 alpha-acetoxy-18 beta-H-28-oic acid (7) and stigmast-5-en-3 beta-ol-3 beta-D-glucuronopyranoside (8). Among them, compound 5 and 6 were new fatty acid ester isolated from this plant. Compound 7 showed MIC 32 mu g/mL against E. coli which was comparable to amoxicillin having same MIC 32 mu g/mL. Compound 5 and 6 showed significant antioxidant activity by inhibiting DPPH due to the presence of phenolic groups.