奥氮平开环杂质 | 138564-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 奥氮平开环杂质
• 英文名称: 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine
• 英文别名: [2-(2-aminoanilino)-5-methylthiophen-3-yl]-(4-methylpiperazin-1-yl)methanone
• CAS: 138564-61-1
• 化学式: C₁₇H₂₂N₄OS
• 分子量: 330.4
• InChiKey: NVVVXCDSGMPBCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] A PROCESS FOR PRODUCING PURE FORM OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-b][1,5]BENZODIAZEPINE<br/>[FR] PROCEDE PERMETTANT DE PRODUIRE UNE FORME PURE DE 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-B][1,5]BENZODIAZEPINE
  申请人：JUBILANT ORGANOSYS LTD

  公开号：WO2006006180A1

  公开（公告）日：2006-01-19

  Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-­thieno[2,3-b][1,5] benzodiazepine. The process comprises of reacting 2-(2-aminoanilino)-5-­methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.

  揭示了一种生产纯2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烯的方法。该方法包括将2-(2-氨基苯胺基)-5-甲基噻吩-3-碳腈与N-甲基哌嗪和N-甲基哌嗪酸盐一起反应，以产生2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烯。还揭示了通过在溶剂混合物中结晶粗2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烯来获得2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烯的多形式I的方法。
• Process for Producing Pure Form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10H-Thieno[2,3-b] [1,5]Benzodiazepine
  申请人：Shastri Jwalant Ashesh

  公开号：US20090005556A1

  公开（公告）日：2009-01-01

  Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. The process comprises of reacting 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.

  揭示了一种生产2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烷的纯形式的方法。该方法包括将2-(2-氨基苯胺基)-5-甲基噻吩-3-羧腈与N-甲基哌嗪以及N-甲基哌嗪酸盐一起反应，以产生2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烷。还揭示了一种通过在溶剂混合物中结晶粗2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烷来获得2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩[2,3-b][1,5]苯二氮杂环己烷的多型形式的方法。
• PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE POLYMORPHIC FORM I OF OLANZAPINE
  申请人：Kozluk Tomasz

  公开号：US20100137581A1

  公开（公告）日：2010-06-03

  A process for preparation of substantially pure polymorphic Form I of olazapine consists in that olanzapine starting material is subjected to: a) at least one digestion step in an acidic aqueous medium, with an optional addition of active charcoal, and then to neutralizing to pH within the range from about 6.0 to about 11.0, and b) at least one step of separation of impurities in a water—organic solvent system, followed by crystallization from the solution in methylene chloride, and wherein steps a) and b) are separated by steps of isolation of precipitate of olanzapine and can be accomplished in any order.

  制备olazapine的基本纯形态I的过程包括以下步骤：将olanzapine原料置于酸性水介质中至少进行一次消化步骤，可选择添加活性炭，然后将pH值中和至约6.0至约11.0之间，以及在水有机溶剂体系中至少进行一次杂质分离步骤，随后在氯仿中结晶，其中步骤a）和b）由olanzapine的沉淀隔开，可以按任意顺序完成。
• A process for producing pure form form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10h-thieno[2,3-B][1,5] benzodiazepine
  申请人：Jubilant Organosys Limited

  公开号：EP2264016A2

  公开（公告）日：2010-12-22

  Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. The process comprises condensing 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine or a salt thereof with N-methyl piperazine to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine, wherein the process is carried out in the absence of a solvent. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.

  本发明公开了一种生产纯态 2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓的工艺。该工艺包括将 4-氨基-2-甲基-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓或其盐与 N-甲基哌嗪缩合，生成 2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓，其中该工艺在无溶剂的情况下进行。还公开了一种在混合溶剂中结晶粗制 2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓，从而获得 2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓多晶型 I 的工艺。
• A PROCESS FOR THE PREPARATION OF OLANZAPINE AND AN INTERMEDIATE THEREFOR
  申请人：Adamed SP. Z O.O.

  公开号：EP1513845B2

  公开（公告）日：2010-11-03