2-[(E)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-(1-methylbenzimidazol-2-yl)ethenyl]-4-methyl-1,3-thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2-[(E)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-(1-methylbenzimidazol-2-yl)ethenyl]-4-methyl-1,3-thiazole
• 化学式: C₂₂H₁₉N₃O₂S
• 分子量: 389.5
• InChiKey: OBIYWMHJJPOKIH-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] C-MYC LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME<br/>[FR] LIGANDS C-MYC CAPABLES DE SE DIMÉRISER DANS UNE SOLUTION AQUEUSE, ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：COFERON INC

  公开号：WO2016115360A1

  公开（公告）日：2016-07-21

  Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding sites on c-Myc.