Fenlean

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Fenlean
• 英文别名: (E)-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
• 化学式: C₂₆H₂₇NO₆
• 分子量: 449.5
• InChiKey: ZZTHOXZXWINLQI-HYARGMPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  97.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• FENLEAN (FLZ) CRYSTAL B FORM, PREPARATION METHOD, AND COMPOSITION AND USE THEREOF
  申请人：Institute of Mataria Medica, Chinese Academy of Medical Sciences

  公开号：EP3653601A1

  公开（公告）日：2020-05-20

  The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

  本发明公开了一种酚醛胺的B型晶态、其制备方法及其组合物和用途，更特别地公开了一种酚醛胺化合物（化学名称：反式-2-(2,5-二甲氧基苯基)-3-(4-羟基-3-甲氧基苯基)-N-(4-羟基苯基乙基)丙烯酰胺的B型晶态、其制备方法及其组合物和用途。具体而言，本发明公开了一种固态 B 型酚胺晶型固体；一种制备该固态 B 型晶型固体的方法；以及将该固态 B 型酚胺晶型固体作为药物活性成分用于制造预防和治疗帕金森病（PD）、改善学习和记忆障碍以及治疗记忆力减退和阿尔茨海默病（AD）的药物。
• FENLEAN (FLZ) CRYSTAL G FORM, PREPARATION METHOD, AND COMPOSITION AND USE THEREOF
  申请人：Institute of Mataria Medica, Chinese Academy of Medical Sciences

  公开号：EP3653603A1

  公开（公告）日：2020-05-20

  The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

  本发明公开了一种酚醛胺的G型晶型、其制备方法及其组合物和用途。特别是，本发明公开了酚胺化合物（化学名称：反式-2-(2,5-二甲氧基苯基)-3-(4-羟基-3-甲氧基苯基)-N-(4-羟基苯基乙基)丙烯酰胺的G型晶型、其制备方法以及其组合物和用途。具体而言，本发明公开了一种固态的G型酚胺晶型固体；一种制备该G型晶型固体的方法；以及将该G型酚胺晶型固体作为药物活性成分用于制造一种预防和治疗帕金森病（PD）、改善学习和记忆障碍、治疗记忆力减退和阿尔茨海默病（AD）的药物。
• Type-B fenolamine crystal form, preparation method, composition and use thereof
  申请人：INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US11059773B2

  公开（公告）日：2021-07-13

  The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

  本发明公开了一种酚醛胺的B型晶态、其制备方法及其组合物和用途，更特别地公开了一种酚醛胺化合物（化学名称：反式-2-(2,5-二甲氧基苯基)-3-(4-羟基-3-甲氧基苯基)-N-(4-羟基苯基乙基)丙烯酰胺的B型晶态、其制备方法及其组合物和用途。具体而言，本发明公开了一种固态 B 型酚胺晶型固体；一种制备该固态 B 型晶型固体的方法；以及将该固态 B 型酚胺晶型固体作为药物活性成分用于制造预防和治疗帕金森病（PD）、改善学习和记忆障碍以及治疗记忆力减退和阿尔茨海默病（AD）的药物。
• Type-G crystal form of fenolamine, preparation method, composition and use thereof
  申请人：INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US11236041B2

  公开（公告）日：2022-02-01

  The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

  本发明公开了一种酚醛胺的G型晶型、其制备方法及其组合物和用途。特别是，本发明公开了酚胺化合物（化学名称：反式-2-(2,5-二甲氧基苯基)-3-(4-羟基-3-甲氧基苯基)-N-(4-羟基苯基乙基)丙烯酰胺的G型晶型、其制备方法以及其组合物和用途。具体而言，本发明公开了一种固态的G型酚胺晶型固体；一种制备该G型晶型固体的方法；以及将该G型酚胺晶型固体作为药物活性成分用于制造一种预防和治疗帕金森病（PD）、改善学习和记忆障碍、治疗记忆力减退和阿尔茨海默病（AD）的药物。
• [EN] PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF<br/>[FR] DÉRIVÉ DE PHOSPHAMIDE, SON PROCÉDÉ DE FABRICATION ET SES UTILISATIONS<br/>[ZH] 一种磷酰胺衍生物及制备方法和用途
  申请人：SICHUAN HAISCO PHARMACEUTICAL CO LTD

  公开号：WO2017133517A1

  公开（公告）日：2017-08-10

  公开了一种磷酰胺衍生物及制备方法和用途。特别公开了一种通式(I)所示化合物及其药学上可接受的盐或立体异构体 (I)，其中，G、L、Q、s如说明书中所定义。