(2R,5R)-6-庚炔-2,5-二胺 | 88192-22-7

• 分子结构分类: 有机化合物 - 乙炔化物
• 中文名称: (2R,5R)-6-庚炔-2,5-二胺
• 英文名称: 6-Heptyne-2,5-diamine, (2R,5R)-
• 英文别名: (2R,5R)-hept-6-yne-2,5-diamine
• CAS: 88192-22-7
• 化学式: C₇H₁₄N₂
• 分子量: 126.2
• InChiKey: QIADQCOYEFCREQ-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R,5R)-6-庚炔-2,5-二胺 、 苯甲酰氯 生成 N-(5-benzamidohept-6-yn-2-yl)benzamide
  参考文献：
  名称：

  VERKOELEN, CARL F.;ROMIJN, JOHAN C.;SCHROEDER, FRITZ H.;VAN, SCHALKWIJK W+, J. CHROMATOGR.-BIOMED. APPL., 426,(1988) N 1, 41-54

  摘要：

  DOI：

文献信息

• LIGHT-DRIVEN ROTARY MOLECULAR MOTORS
  申请人：Bell Thomas W.

  公开号：US20110077394A1

  公开（公告）日：2011-03-31

  Compounds of Formula (1) are disclosed. C b is a carbocyclic or heterocyclic group having an atom within the cyclic structure selected from C, N, Si, and C r and singly bound to A. A is CR, COR, CSR, CNR 2 , CCN, CCONR 2 , CNO 2 , CNNAr, CX′, or N. C r is a chromophore having a substantially planar cyclic structure. The compounds function as nanometer-scale rotary molecular motors powered and controlled by light energy. The design of the molecular motor devices is flexible so that the rotary direction, drive light wavelength, and other physical characteristics can be varied. The compounds can be chemically functionalized to allow it to be integrated into or attached to a variety of structures. The device can be used in applications where mechanical power, positional control, and information encoding are to be generated at the size scale of individual molecules.

  式（1）的化合物已被披露。 C b 是一个具有环结构内选自C、N、Si和C r 的原子的碳环或杂环基团，并与A单键相连。A是CR、COR、CSR、CNR 2 、CCN、CCONR 2 、CNO 2 、CNNAr、CX′或N。C r 是具有基本平面环结构的色团。这些化合物作为受光能驱动和控制的纳米尺度旋转分子马达。分子马达装置的设计灵活，使得旋转方向、驱动光波长和其他物理特性可以变化。这些化合物可以在化学上官能化，以使其能够集成到或附着到各种结构中。该装置可用于需要在单个分子尺度上产生机械动力、位置控制和信息编码的应用中。
• S-Adenosylmethionine decarboxylase inhibitors
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0351475A1

  公开（公告）日：1990-01-24

  This invention relates to novel chemical compounds useful as S-adenosylmethionine decarboxylase inhibitors, of the formula H₂N-Q--Al wherein Al represents 5'-deoxyadenosyl.      represents adenosinyl, R represents H, methyl or ethyl and Q represents moieties of formulae Ia to If depicted as follows: wherein R₁ is H or F, n is 1 or 2, V₁ is H or CH₃, V₂ is H or COOH, and each of W, X, Y, and Z are H, F, Cl or Br. To the processes useful for their preperation and to their use in the treatment of a variety of condition and disease states associated with a rapid proliferation of cell growth.

  这项发明涉及一种新型化合物，可用作S-腺苷甲硫氨酸脱羧酶抑制剂，其化学式为H₂N-Q--Al，其中Al代表5'-去氧腺苷基。     代表腺苷基，R代表H、甲基或乙基，Q代表如下所示的化学式Ia至If的基团：其中R₁为H或F，n为1或2，V₁为H或CH₃，V₂为H或COOH，而W、X、Y和Z中的每一个均为H、F、Cl或Br。还涉及用于其制备的方法以及它们在治疗与细胞增殖快速增加相关的各种疾病和病症中的应用。
• Use of ornithine decarboxylase inhibitor for preparing a medicament for use in the treatment, in conjuction with LAK cells and interleukin-2, of tumors
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0248217A2

  公开（公告）日：1987-12-09

  Ornithine decarboxylase inhibitors when administered in conjunction with autologous LAK cells and interleukin-2 provide for an enhanced treatment of neoplastic disease states. This enhancement is provided by the ability of an ornithine decarboxylase inhibitor to reduce tumor load and to enhance interleukin-2 production in T helper cells.

  鸟氨酸脱羧酶抑制剂与自体 LAK 细胞和白细胞介素-2 结合使用，可增强对肿瘤性疾病的治疗。鸟氨酸脱羧酶抑制剂能够减少肿瘤负荷，并促进 T 辅助细胞产生白细胞介素-2，从而提高治疗效果。
• Gem-dihalo-1,8-diamino-4-aza-octanes
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0215319B1

  公开（公告）日：1991-10-16
• Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0220409B1

  公开（公告）日：1991-11-27