(6-氟-4H-1,3-苯并二恶-8-基)甲胺 | 306934-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 中文名称: (6-氟-4H-1,3-苯并二恶-8-基)甲胺
• 英文名称: C-(6-fluoro-4H-benzo[1,3]dioxin-8-yl)-methylamine
• 英文别名: (6-fluoro-4H-1,3-benzodioxin-8-yl)methylamine；(6-fluoro-4H-1,3-benzodioxin-8-yl)methanamine
• CAS: 306934-88-3
• 化学式: C₉H₁₀FNO₂
• mdl: MFCD02677704
• 分子量: 183.182
• InChiKey: JNFVSJNYOFOUDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  C
• 安全说明：
  S26,S36/37/39,S45

反应信息

• 作为反应物：
  描述：

  (6-氟-4H-1,3-苯并二恶-8-基)甲胺 、 丙烯酰氯 在 Amberlyst A₂₆ (OH-form) 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 0.16h， 以50%的产率得到N-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)acrylamide
  参考文献：
  名称：

  Efficient and Facile Synthesis of Acrylamide Libraries for Protein-Guided Tethering

  摘要：

  A kinetic template-guided tethering (KTGT) strategy has been developed for the site-directed discovery of fragments that bind to defined protein surfaces, where acrylamide-modified fragments can be irreversibly captured in a protein-templated conjugate addition reaction. Herein, an efficient and facile method is reported for the preparation of acrylamide libraries from a diverse range of amine fragments using a solid-supported quaternary amine base.

  DOI：

  10.1021/ol503486t

文献信息

• Pyrrole Derivatives As Pharmaceutical Agents
  申请人：Canne Bannen Lynne

  公开号：US20080234270A1

  公开（公告）日：2008-09-25

  Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

  提供了用于调节受体活性的化合物、组合物和方法。特别提供了用于调节受体活性的化合物和组合物，以及用于治疗、预防或改善与受体活性直接或间接相关的一种或多种疾病或紊乱的症状的方法。
• 2-(Amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
  申请人：Fleming E. Paul

  公开号：US20060040968A1

  公开（公告）日：2006-02-23

  A heterocyclic inhibitor having the formula I, with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role:

  一种杂环抑制剂，具有以下公式I，其中变量在此定义，可用于治疗PKC-theta亚型在其中起作用的炎症和其他生理紊乱：
• Amino-tetrazole analogues and methods of use
  申请人：Carroll A. William

  公开号：US20060052374A1

  公开（公告）日：2006-03-09

  A compound having Formula (I) or Formula (II) is disclosed as an P2X 7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R 1 , R 2 , R 3 , R 4 , and R 5 , are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X 7 are also disclosed.

  本文披露一种化合物，其化学式为（I）或（II），作为P2X7拮抗剂，其中A、B、C、Y、Y、Z、m、v、R1、R2、R3、R4和R5如描述中所定义。同时，本文还披露了治疗P2X7调节的疾病或病症的方法和组合物。
• Pyrazolopyrimidines as cyclin dependent kinase inhibitors
  申请人：Guzi J. Timothy

  公开号：US20070225270A1

  公开（公告）日：2007-09-27

  In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的嘧唑并[1,5-a]嘧啶化合物类作为细胞周期蛋白依赖性激酶的抑制剂，制备这种化合物的方法，含有一种或多种这种化合物的制药组合物，制备包含一种或多种这种化合物的制药制剂的方法，以及使用这种化合物或制药组合物治疗、预防、抑制或缓解与CDKs相关的一种或多种疾病的方法。
• Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
  申请人：Guzi J. Timothy

  公开号：US20080050384A1

  公开（公告）日：2008-02-28

  In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的吡唑并[1,5-a]嘧啶化合物类作为细胞周期依赖性激酶抑制剂，制备这种化合物的方法，包含一种或多种这样的化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法，以及使用这样的化合物或药物组合物治疗、预防、抑制或改善与CDKs相关的一种或多种疾病的方法。