(6R-反)-3-[(乙酰氧基)甲基]-7-氨基-8-羰基-5-硫杂-1-氮杂二环[4.2.0]辛-2-烯-2-羧酸钠 | 81503-63-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: (6R-反)-3-[(乙酰氧基)甲基]-7-氨基-8-羰基-5-硫杂-1-氮杂二环[4.2.0]辛-2-烯-2-羧酸钠
• 中文别名: 2-氨基-2'-脱氧腺苷5'-三磷酸酯
• 英文名称: 2-aminodeoxyadenosine 5'-triphosphate
• 英文别名: 2-Amino-2'-deoxyadenosine 5'-(tetrahydrogen triphosphate)；[[(2R,3S,5R)-5-(2,6-diaminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 81503-63-1
• 化学式: C₁₀H₁₇N₆O₁₂P₃
• 分子量: 506.199
• InChiKey: JFVJZFMWJVSZNC-KVQBGUIXSA-N

物化性质

• 沸点：
  1007.2±75.0 °C(Predicted)
• 密度：
  2.63±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  285
• 氢给体数：
  7
• 氢受体数：
  17

文献信息

• Method of producing nucleic acid molecules with reduced secondary structure
  申请人：Agilent Technologies Inc.

  公开号：EP1072679A2

  公开（公告）日：2001-01-31

  The present invention provides a system for generating nucleic acid molecules having reduced levels of secondary structure compared to nucleic acid molecules of the same nucleotide sequence containing only naturally-occurring bases. Such molecules are referred to herein as "unstructured nucleic acids" (UNAs). UNAs have reduced levels of secondary structure because of their reduced ability to form intramolecular hydrogen bond base pairs between regions of substantially complementary sequence. Preferred UNAs, however, retain the ability to form intermolecular hydrogen bond base pairs with other nucleic acid molecules.

  本发明提供了一种生成核酸分子的系统，与仅含有天然碱基的相同核苷酸序列的核酸分子相比，这种核酸分子的二级结构水平较低。这种分子在此称为 "非结构化核酸"（UNAs）。由于 UNAs 在基本互补序列区域之间形成分子内氢键碱基对的能力减弱，因此二级结构水平降低。不过，优选的 UNAs 仍具有与其它核酸分子形成分子间氢键碱基对的能力。
• Synthesis of nucleic acid
  申请人：Agilent Technologies, Inc. (a Delaware corporation)

  公开号：EP1225234A2

  公开（公告）日：2002-07-24

  A nucleic acid molecule to be sequenced is generated having tandem repeats of a sequence, and also having modified nucleotides which reduce the levels of secondary structure. The presence of tandemly repeated sequence and the absence of secondary structure increases the rate of sequencing and accuracy of sequences generated by nanopore sequencing. A method comprises the steps of: providing two separate, adjacent solutions of a medium and an interface between the two pools, the interface having a channel so dimensioned as to allow sequential nucleotide-by-nucleotide passage from one pool to the other pool of only one nucleic acid molecule at a time; providing a nucleic acid molecule with at least one repeat of a nucleotide sequence to be determined, wherein the nucleic acid molecule is enzymatically synthesized using a circular template, and wherein the nucleic acid molecule contains modified nucleotides that reduce secondary structure in the nucleic acid molecule; placing the nucleic acid molecule in one of the two pools; and taking measurements as each of the nucleotides of the nucleic acid molecule passes through the channel so as to determine the sequence of the nucleic acid molecule.

  待测序的核酸分子具有串联重复序列，还具有可降低二级结构水平的修饰核苷酸。串联重复序列的存在和二级结构的缺失可提高测序速度和纳米孔测序生成序列的准确性。一种方法包括以下步骤提供两个独立的、相邻的介质溶液和两个池之间的界面，界面具有一个通道，其尺寸允许每次只有一个核酸分子从一个池逐个核苷酸顺序通过到另一个池；提供具有至少一个待测定核苷酸序列重复的核酸分子，其中核酸分子是使用环形模板酶切合成的，并且其中核酸分子含有可减少核酸分子中二级结构的修饰核苷酸；将核酸分子放入两个池中的一个；当核酸分子的每个核苷酸通过通道时进行测量，以确定核酸分子的序列。
• Functional ligands to nerve agent metabolites
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US10059951B2

  公开（公告）日：2018-08-28

  This invention relates to functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, more particularly to functional ligands with binding affinity to metabolites of nerve agents, and further particularly to functional ligands with binding affinity to metabolites of VX-acid (metabolite of VX nerve agent) and GB-acid (metabolite of sarin nerve agent).

  本发明涉及目标分子的功能配体，特别是功能核酸及其修饰，更特别的是与神经毒剂代谢物具有结合亲和力的功能配体，进一步特别是与 VX 酸（VX 神经毒剂的代谢物）和 GB 酸（沙林神经毒剂的代谢物）的代谢物具有结合亲和力的功能配体。
• Functional ligands to target molecules
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US10415041B2

  公开（公告）日：2019-09-17

  The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as amino acids, such as citrulline, and to target molecules such as crystallin or its subunits, such as alpha crystallin B-chain (CRYAB).

  本发明涉及与靶分子有关的功能配体，特别是与功能核酸及其修饰有关的功能配体，以及同时产生例如多种不同功能生物分子的方法，特别是同时针对多个靶分子产生多种不同功能核酸的方法。本发明进一步涉及与目标分子（如氨基酸，如瓜氨酸）和目标分子（如结晶素或其亚基，如α结晶素B链（CRYAB））亲和结合的功能配体。
• Sample preparation method
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10669578B2

  公开（公告）日：2020-06-02

  The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.

  本发明涉及一种表征模板多核苷酸的改进方法。该方法包括使用聚合酶制备修饰的多核苷酸，使其比模板多核苷酸更容易表征。