(8alpha,9beta)-6,8-二甲基麦角灵-9-醇 | 6879-93-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 中文名称: (8alpha,9beta)-6,8-二甲基麦角灵-9-醇
• 英文名称: Fumigaclavin B
• 英文别名: fumigaclavine B；(6aR,9R,10S,10aR)-7,9-dimethyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-10-ol
• CAS: 6879-93-2
• 化学式: C₁₆H₂₀N₂O
• 分子量: 256.348
• InChiKey: JUXRVSRUBIFVKE-BBDZHYCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Production of lysergic acid by genetic modification of a fungus
  申请人：West Virigina University

  公开号：US10370689B2

  公开（公告）日：2019-08-06

  The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) or any fungus having a pathway similar to Aspergillus fumigatus and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus or said fungus having a pathway similar to Aspergillus fumigatus, is provided.

  本发明提供了一种通过遗传修饰真菌生产麦角酸和其他麦角生物碱的方法。一株真菌包括烟曲霉（A. fumigatus）或任何具有与烟曲霉相似途径的真菌，并表达麦角生物碱生物合成途径的一个或多个基因，该基因来自选自Epichloë festucae var.lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1)；Claviceps species；Claviceps africana (C.africana)；Claviceps gigantea (C.gigantea)；Epichloë coenophiala 和 Periglandula species，其中基因 easA 或基因 easM 在所述烟曲霉或所述具有与烟曲霉相似途径的真菌中失活。
• GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS
  申请人：BASF SE

  公开号：EP2888351A2

  公开（公告）日：2015-07-01
• PRODUCTION OF LYSERGIC ACID BY GENETIC MODIFICATION OF A FUNGUS
  申请人：West Virginia University

  公开号：EP3155093A2

  公开（公告）日：2017-04-19
• METHOD FOR PRODUCING DRIMANYL ACETATE COMPOUNDS
  申请人：Firmenich SA

  公开号：EP3827089A1

  公开（公告）日：2021-06-02
• METHODS AND COMPOSITIONS COMPRISING A 5HT RECEPTOR AGONIST FOR THE TREATMENT OF PSYCHOLOGICAL, COGNITIVE, BEHAVIORAL, AND/OR MOOD DISORDERS
  申请人：Diamond Therapeutics Inc.

  公开号：EP3917537A1

  公开（公告）日：2021-12-08