(8beta)-9,10-二去氢-N-(4-羟基丁基)-1,6-二甲基-麦角灵-8-甲酰胺 | 4238-82-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 中文名称: (8beta)-9,10-二去氢-N-(4-羟基丁基)-1,6-二甲基-麦角灵-8-甲酰胺
• 中文别名: 二[O,O-二(2-乙基己基)]二(二硫代磷酸)锌
• 英文名称: Ergoline-8-carboxamide, 9,10-didehydro-N-(4-hydroxybutyl)-1,6-dimethyl-, (8beta)-
• 英文别名: (6aR,9R)-N-(4-hydroxybutyl)-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
• CAS: 4238-82-8
• 化学式: C₂₁H₂₇N₃O₂
• 分子量: 353.5
• InChiKey: DTLDCNXIJXGHKW-DNVCBOLYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• US4235912A
  申请人：——

  公开号：US4235912A

  公开（公告）日：1980-11-25
• [EN] 5-HT3 RECEPTOR ANTAGONISTS FOR TREATMENT OF DISORDERS INVOLVING AIRWAY CONSTRICTION<br/>[FR] ANTAGONISTES DU RECEPTEUR 5-HT3 DESTINES AU TRAITEMENT DE TROUBLES ENGLOBANT LA CONSTRICTION DES VOIES AERIENNES
  申请人：RESPIRATORIUS AB

  公开号：WO2001095903A1

  公开（公告）日：2001-12-20

  The present invention relates to a compound having antagonist activity to the 5-HT3 receptor for use as a medicament and to the use of said compound in the manufacture of a medicament for use in therapeutic or prophylactic treatment of disorders involving airway constriction of a human or animal body, as well as methods of treatment, wherein said compounds are administered.
• [EN] A COMPOSITION COMPRISING A COMBINATION OF RECEPTOR AGONISTS AND ANTAGONISTS<br/>[FR] COMPOSITION CONTENANT UNE ASSOCIATION D'AGONISTES ET D'ANTAGONISTES D'UN RECEPTEUR
  申请人：RESPIRATORIUS AB

  公开号：WO2001095902A1

  公开（公告）日：2001-12-20

  The present invention relates to a composition comprising a combination of a) at least one compound with agonist activity to the 5-HT4 receptor and b) at least one compound with antagonist activity to the 5-HT3 receptor and to the use of said compound in the manufacture of a medicament for therapeutic or prophylactic treatment of disorders involving airway constriction of a human or animal body, as well as methods of treatment, wherein said compounds are administered.
• [EN] COMPOSITION COMPRISING: SEROTONIN RECEPTOR ANTAGONISTS (5HT-2, 5HT-3) AND AGONIST (5HT-4)<br/>[FR] COMPOSITION COMPRENANT DES AGONISTES (5HT-4) ET DES ANTAGONISTES (5HT-2, 5HT-3) RECEPTEURS DE LA SEROTONINE
  申请人：RESPIRATORIUS AB

  公开号：WO2002036113A1

  公开（公告）日：2002-05-10

  A composition comprising a combination of a) at least one compound with agonist activity to the 5-HT4 receptor, b) at least one compound with antagonist activity to the 5-HT3 receptor, and c) at least one compound with antagonist activity to the 5-HT2 receptor is described.
• [EN] COMPOSITION COMPRISING SEROTONIN RECEPTOR ANTAGONISTS, 5 HT-2 AND 5 HT-3<br/>[FR] COMPOSITION COMPRENANT LES ANTAGONISTES DES RECEPTEURS DE SEROTONINE 5 HT-2 ET 5 HT-3
  申请人：RESPIRATORIUS AB

  公开号：WO2002036114A1

  公开（公告）日：2002-05-10

  A composition comprising a combination of compounds comprising: a) at least one compound with antagonist activity to the 5-HT3 receptor; and b) at least one compound with antagonist activity to the 5-HT2 receptor is described.