2-[2-(dimethylamino)ethylthio]-1-[1-(2-naphthyl)cyclobutyl]ethanone | 161190-03-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[2-(dimethylamino)ethylthio]-1-[1-(2-naphthyl)cyclobutyl]ethanone
• 英文别名: 2-[2-(dimethylamino)ethylthio]-l-[1-(2-naphthyl)cyclobutyl]ethanone；2-[2-(Dimethylamino)ethylsulfanyl]-1-(1-naphthalen-2-ylcyclobutyl)ethanone
• CAS: 161190-03-0
• 化学式: C₂₀H₂₅NOS
• 分子量: 327.491
• InChiKey: HOOXJQWBWVOOOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] 1-ARYLCYCLOALKYL SULPHIDES, SULPHOXIDES AND SULPHONES FOR THE TREATMENT OF DEPRESSION, ANXIETY AND PARKINSON'S DISEASE<br/>[FR] SULFURES, OXYDES SULFONIQUES ET SULFONES DE 1-ARYLCYCLOALKYLE UTILISES POUR LE TRAITEMENT DE LA DEPRESSION, DE L'ANXIETE ET DE LA MALADIE DE PARKINSON
  申请人：THE BOOTS COMPANY PLC

  公开号：WO1994026704A1

  公开（公告）日：1994-11-24

  (EN) Compounds of formula (I) and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula (II) in which R5 is H or alkyl; Y is an alkylene chain optionally substituted by one or more alkyl groups; Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups; R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R1 and R2, which are the same or different, are H, alkyl, or arylalkyl, provided that when R1 is benzyl, R2 is H or methyl; have utility in the treatment of depression, anxiety, Parkinsons' disease, obesity, cognitive disorders, seizures, neurological disorders such as epilepsy, and as neuroprotective agents to protect agains conditions such as stroke.(FR) L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, m correspondant à 1, 1 ou 1; n à 2, 3, 4 ou 5; X représentant carbonyle ou un groupe de formule (II) dans laquelle R5 représente H ou alkyle; Y représentant une chaîne alkylène éventuellement substituée par un ou plusieurs groupes alkyle; Z représentant une chaîne alkylène contenant 2 à 5 atomes de carbone éventuellement substitués par un ou plusieurs groupes alkyle; R représentant phényle éventuellement substitué par un ou plusieurs substituants halo ou R représentant naphtyle; et R1 et R2, qui sont identiques ou différents représentent H, alkyle, ou aralkyle à condition que lorsque R1 représente benzyle; R2 représente H ou méthyle. Lesdites composés sont utiles dans le traitement de la dépression, de l'anxiété, de la maladie de Parkinson, de l'obésité, de troubles neurologiques tels que l'épilepsie, et en tant qu'agents neuroprotecteurs contre l'ictus.

  (中文) 公式（I）的化合物及其药学上可接受的盐，其中m为0、1或2；n为2、3、4或5；X为羰基或公式（II）中R5为H或烷基的基团；Y为一种可选地由一个或多个烷基取代的烷基链；Z为一种含有2至5个碳原子的烷基链，可选地由一个或多个烷基取代；R为苯基，可选地取代一个或多个卤素基团，或者R为萘基；R1和R2相同或不同，分别为H、烷基或芳基烷基，但当R1为苄基时，R2为H或甲基。该化合物在治疗抑郁症、焦虑症、帕金森病、肥胖症、认知障碍、癫痫等神经系统疾病以及作为神经保护剂，保护免受中风等疾病的影响方面具有用途。
• Therapeutic agents
  申请人：Luscombe Paul Graham

  公开号：US20050182141A1

  公开（公告）日：2005-08-18

  Substituted cycloalkyl compounds with 3 to 6 carbon atoms in the ring, one carbon linked to each of two side groups R and R′, and pharmaceutically acceptable salts thereof in which R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R′ is —[X—Y—S(O) m -Z-N—R 1 —R 2 ], wherein X is carbonyl or a carbon directly linked to each of a hydroxyl group and R 5 in which R 5 is H or alkyl, Y is an alkylene chain optionally substituted by one or more alkyl groups, m can be 0, 1 or 2, Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups, and R 1 and R 2 , which are the same or different, are H, alkyl, or arylalkyl, provided that when R 1 is benzyl, R 2 is H or methyl; have utility in the treatment of drug misuse or other addictive disorders.

  环中有 3 至 6 个碳原子、两个侧基 R 和 R′各连接一个碳的被取代环烷基化合物及其药学上可接受的盐，其中 R 是任选被一个或多个卤代基取代的苯基或 R 是萘基；R′是-[X-Y-S(O) m -Z-N-R 1 -R 2 其中 X 是羰基或直接与羟基和 R 5 其中 R 5 是 H 或烷基，Y 是任选被一个或多个烷基取代的亚烷基链，m 可以是 0、1 或 2，Z 是含有 2 至 5 个碳原子任选被一个或多个烷基取代的亚烷基链，以及 R 1 和 R 2 是 H、烷基或芳烷基，但当 R 1 为苄基时，R 2 是 H 或甲基；可用于治疗药物滥用或其他成瘾性疾病。
• 1-ARYLCYCLOALKYL SULPHIDES, SULPHOXIDES AND SULPHONES FOR THE TREATMENT OF DEPRESSION, ANXIETY AND PARKINSON'S DISEASE
  申请人：Knoll AG

  公开号：EP0715620A1

  公开（公告）日：1996-06-12
• THERAPEUTIC AGENTS
  申请人：Knoll GmbH

  公开号：EP1198229A1

  公开（公告）日：2002-04-24
• Therapeutic Agents
  申请人：Luscombe Paul Graham

  公开号：US20070129445A1

  公开（公告）日：2007-06-07

  Substituted cycloalkyl compounds with 3 to 6 carbon atoms in the ring, one carbon linked to each of two side groups R and R′, and pharmaceutically acceptable salts thereof in which R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R′ is —[X—Y—S(O) m —Z—N—R 1 —R 2 ], wherein X is carbonyl or a carbon directly linked to each of a hydroxyl group and R 5 in which R 5 is H or alkyl, Y is an alkylene chain optionally substituted by one or more alkyl groups, m can be 0, 1 or 2, Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups, and R 1 and R 2 , which are the same or different, are H, alkyl, or arylalkyl, provided that when R 1 is benzyl, R 2 is H or methyl; have utility in the treatment of drug misuse or other addictive disorders.