8-(2-Tert-butylanilino)naphthalene-1-sulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-(2-Tert-butylanilino)naphthalene-1-sulfonic acid
• 化学式: C₂₀H₂₁NO₃S
• 分子量: 355.5
• InChiKey: JKWWASIZEUXOEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 8-(anilino)-1-naphthalenesulfonate analogs and their use in analyte detection assays
  申请人：Lifescan, Inc.

  公开号：EP1510555A1

  公开（公告）日：2005-03-02

  8-(anilino)-1-naphthalenesulfonate (ANS) analogs and methods for their use in analyte detection assays are provided. The subject ANS analogs are characterized by having at least one non-hydrogen substituent on their phenyl moiety and producing a reaction product with 3-methyl-benzothiazolinone hydrazone hydrochloride (MBTH) or an analog thereof, e.g. MBTHSB, that exhibits reduced drift. In certain preferred embodiments, the subject ANS analogs are described by formula (I) wherein: n is 1 to 5; and X is a substituent other than H. The subject ANS analogs find use in a variety of applications, particularly in analyte detection assays, such as glucose detection assays.

  本发明提供了 8-(苯胺基)-1-萘磺酸盐 (ANS) 类似物及其用于分析物检测测定的方法。所述 ANS 类似物的特征在于其苯基上至少有一个非氢取代基，并且与 3-甲基-苯并噻唑啉酮腙盐酸盐（MBTH）或其类似物（如 MBTHSB）生成的反应产物漂移减小。在某些优选的实施方案中，所述 ANS 类似物由式（I）描述，其中：n 是 1 至 5；X 是除 H 以外的取代基。
• 8-(ANILINO)-1-NAPHTHALENESULFONATE ANALOGS AND THEIR USE IN ANALYTE DETECTION ASSAYS
  申请人：Lifescan, Inc.

  公开号：EP1224240A1

  公开（公告）日：2002-07-24
• US6218571B1
  申请人：——

  公开号：US6218571B1

  公开（公告）日：2001-04-17
• [EN] 8-(ANILINO)-1-NAPHTHALENESULFONATE ANALOGS AND THEIR USE IN ANALYTE DETECTION ASSAYS<br/>[FR] ANALOGUES DE 8-(ANILINO)-1-NAPHTHALENESULFONATE ET LEUR UTILISATION DANS DES DOSAGES DE DETECTIONS D'ANALYTES
  申请人：LIFESCAN INC

  公开号：WO2001030915A1

  公开（公告）日：2001-05-03

  8-(anilino)-1-naphthalenesulfonate (ANS) analogs and methods for their use in analyte detection assays are provided. The subject ANS analogs are characterized by having at least one non-hydrogen substituent on their phenyl moiety and producing a reaction product with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) or an analog thereof, e.g. MBTHSB, that exhibits reduced drift. In certain preferred embodiments, the subject ANS analogs are described by formula (I) wherein: n is 1 to 5; and X is a substituent other than H. The subject ANS analogs find use in a variety of applications, particularly in analyte detection assays, such as glucose detection assays.