1-[2-(1-Naphthalen-1-ylethoxy)cyclohexyl]pyrrolidin-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[2-(1-Naphthalen-1-ylethoxy)cyclohexyl]pyrrolidin-3-one
• 化学式: C₂₂H₂₇NO₂
• 分子量: 337.5
• InChiKey: XPSUXQFRUZDMNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Ion channel modulating activity I
  申请人：Fedida David

  公开号：US20050070552A1

  公开（公告）日：2005-03-31

  Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
• US7674820B2
  申请人：——

  公开号：US7674820B2

  公开（公告）日：2010-03-09
• US8188140B2
  申请人：——

  公开号：US8188140B2

  公开（公告）日：2012-05-29