3-[3-[1-(1H-indol-5-yl)-3,6-dihydro-2H-pyridin-4-yl]propyl]-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-[3-[1-(1H-indol-5-yl)-3,6-dihydro-2H-pyridin-4-yl]propyl]-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide
• 英文别名: 3-[3-[1-(1H-indol-5-yl)-3,6-dihydro-2H-pyridin-4-yl]propyl]-2λ6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide
• 化学式: C₂₆H₂₅N₃O₂S
• 分子量: 443.6
• InChiKey: ONTRFMGLHYDVMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  64.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS
  申请人：H. Lundbeck A/S

  公开号：EP1299384A1

  公开（公告）日：2003-04-09
• [EN] INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS<br/>[FR] DERIVES D'INDOLE SERVANT AU TRAITEMENT DES TROUBLES DU SNC
  申请人：LUNDBECK & CO AS H

  公开号：WO2001098298A1

  公开（公告）日：2001-12-27

  The present invention relates to dopamine and serotonin receptor ligands having the general formula (I) wherein the meanings of Y, Z, W, n, m, X and R1-R12 are as given in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, i. e. schizophrenia and other psychoses, anxiety disorders, depression, migraine, cognitive disorders, attention deficit hyperactivity disorder (ADHD) and sleep improvement.