3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-4-methoxy-2,5-difluorobenzylidene-2,4-thiazolidinedione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-4-methoxy-2,5-difluorobenzylidene-2,4-thiazolidinedione
• 英文别名: (5E)-5-[[2,5-difluoro-4-methoxy-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C₂₆H₂₇F₂NO₃S
• 分子量: 471.568
• InChiKey: INIWNLQZQGHADB-YBFXNURJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Substituted heterocycles for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20060004059A1

  公开（公告）日：2006-01-05

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及公式（I）的某些取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病中有用，例如2型糖尿病，脂肪细胞分化，不受控制的增殖（如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或癌症总体）和炎症（如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病）。
• Imidazolidinedione derivatives for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20050070581A1

  公开（公告）日：2005-03-31

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及某些式(I)的取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病方面是有用的，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或普遍的癌症；以及炎症，例如骨关节炎、类风湿性关节炎、克罗恩病或炎性肠病。
• Thiazolidinedione derivatives for the treatment of diabetes and other diseases
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：US20030153606A1

  公开（公告）日：2003-08-14

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease. 1

  本发明涉及公式(I)的某些取代杂环，其在治疗与脂质和碳水化合物代谢相关的疾病方面有用，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，例如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般的癌症；以及炎症，例如骨关节炎、风湿性关节炎、克隆氏病或炎性肠病。
• Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
  申请人：Incyte San Diego Incorporated

  公开号：EP1593677A2

  公开（公告）日：2005-11-09

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatiod arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及某些取代的式(I)杂环，可用于治疗与脂质和碳水化合物代谢有关的疾病，如 2 型糖尿病、脂肪细胞分化、增殖失控，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般癌症；以及炎症，如骨关节炎、风湿性关节炎、克罗恩病或炎症性肠病。
• BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：EP1214304A1

  公开（公告）日：2002-06-19