5-(2-aminopropyl)-8-bromo-6-methoxy-3,4-dihydro-2H-chromen-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-(2-aminopropyl)-8-bromo-6-methoxy-3,4-dihydro-2H-chromen-3-ol
• 化学式: C₁₃H₁₈BrNO₃
• 分子量: 316.19
• InChiKey: MINQTQPGESMBEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted 5-chroman-5-YL-ethylamine compounds and their use for the treatment of glaucoma
  申请人：May A. Jesse

  公开号：US20050171190A1

  公开（公告）日：2005-08-04

  Substituted 5-chroman-5-yl-ethylamine compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

  本发明公开了取代的 5-色满-5-基-乙胺化合物。还公开了降低和控制正常或升高的眼压的方法，以及使用含有一种或多种本发明化合物的组合物治疗青光眼的方法。
• SUBSTITUTED 5-CHROMAN-5-YL-ETHYLAMINE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF GLAUCOMA
  申请人：Alcon, Inc.

  公开号：EP1545501A2

  公开（公告）日：2005-06-29
• [EN] SUBSTITUTED 5-CHROMAN-5-YL-ETHYLAMINE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF GLAUCOMA<br/>[FR] COMPOSES DE 5-CHROMAN-5-YL-ETHYLAMINE SUBSTITUES ET LEUR UTILISATION DANS LE TRAITEMENT DU GLAUCOME
  申请人：ALCON INC

  公开号：WO2004019874A2

  公开（公告）日：2004-03-11

  Substituted 5-chroman-5-yl-ethylamine compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.