4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)cyclohexane-1-carboxamide;dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)cyclohexane-1-carboxamide;dihydrochloride
• 化学式: C16H24Cl2N4O
• 分子量: 359.3
• InChiKey: FYPVXZRTHRVCAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.8
• 氢给体数：
  5
• 氢受体数：
  3

文献信息

• 4-AMINO(ALKYL)CYCLOHEXANE-1-CARBOXAMIDE COMPOUND AND USE THEREOF
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0641781A1

  公开（公告）日：1995-03-08

  A 4-amino(alkyl)cyclohexane-1-carboxamide compound represented by general formula (I), an isomer thereof, and a pharmaceutically acceptable acid addition salt thereof, wherein each symbol is as defined in the specification. These substances have a remarkable, highly persistent and lowly toxic activity of increasing blood stream in coronary, cerebral, renal and peripheral arteries, and are useful as a potent and persistent hypotensive and a drug for preventing and treating diseases of a cardiovascular system such as coronary, cerebral, renal and peripheral arteries. Furthermore, they are useful as an antasthmatic, because they have activities of inhibiting experimental guinea pig asthma caused by the inhalation of histamine and inhibiting contraction of a specimen of an extirpated guinea pig trachea caused by acetylcholine.

  一种由通式(I)代表的 4-氨基(烷基)环己烷-1-甲酰胺化合物、其异构体及其药学上可接受的酸加成盐，其中各符号如说明书中所定义。这些物质在增加冠状动脉、脑动脉、肾动脉和外周动脉血流方面具有显著、高持久性和低毒性的活性，可用作强效持久的降压药以及预防和治疗冠状动脉、脑动脉、肾动脉和外周动脉等心血管系统疾病的药物。此外，它们还可用作抗哮喘药，因为它们具有抑制由吸入组胺引起的实验性豚鼠哮喘和抑制由乙酰胆碱引起的已切除豚鼠气管标本收缩的活性。
• MEDIUM FOR DIRECT DIFFERENTIATION OF PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELL, METHOD FOR PREPARING MESENCHYMAL STEM CELL BY USING SAME, AND MESENCHYMAL STEM CELL PREPARED THEREBY
  申请人：CHA Biotech Co., Ltd.

  公开号：EP3848455A1

  公开（公告）日：2021-07-14

  The present invention relates to a medium for direct differentiation of embryonic stem cell-derived mesenchymal stem cells, a method of preparing mesenchymal stem cells by using same, mesenchymal stem cells prepared thereby, and a cell therapy product comprising the same mesenchymal stem cells. In a medium composition and a method according to an embodiment, mesenchymal stem cells may be prepared at high yield within a short period of time. In addition, the method is simple in preparation procedure because of the absence of an embryoid body formation step and allows homogeneous cells to be prepared, thus advantageously providing a cell therapy product within a reduce period of time, compared to conventional methods.

  本发明涉及一种用于直接分化胚胎干细胞衍生间充质干细胞的培养基、使用该培养基制备间充质干细胞的方法、由此制备的间充质干细胞以及包含相同间充质干细胞的细胞治疗产品。根据一个实施方案中的培养基组合物和方法，间充质干细胞可在短时间内高产制备。此外，由于没有胚状体形成步骤，该方法制备程序简单，可制备均质细胞，因此与传统方法相比，可在较短时间内提供细胞治疗产品。
• Modeling connections between dopaminergic neurons and the cerebral cortex
  申请人：Freed William J.

  公开号：US10081791B2

  公开（公告）日：2018-09-25

  Disclosed are methods that include separately differentiating stem cells to form cortical neural progenitor cells and differentiating stem cells to form dopaminergic neural progenitor cells. The cortical progenitor cells are transferred to a first compartment of a culture dish and the dopaminergic progenitor cells are transferred to a second compartment of the culture dish, separated by a removable barrier. The cortical progenitor cells and dopaminergic progenitor cells are cultured in medium that promotes differentiation of cortical neurons and dopaminergic neurons, respectively. The barrier is then removed, creating a single chamber containing the cortical progenitor cells and the dopaminergic progenitor cells, separated by a gap. The cortical progenitor cells and the dopaminergic progenitor cells are then cultured in a single medium, which promotes further differentiation of the neurons and also supports formation of connections (such as synapses or synapse-like structures) between at least some of the cortical neurons and dopaminergic neurons.

  公开的方法包括分别分化干细胞以形成皮质神经祖细胞和分化干细胞以形成多巴胺能神经祖细胞。皮质祖细胞被转移到培养皿的第一隔室，多巴胺能祖细胞被转移到培养皿的第二隔室，两者之间用可移动的屏障隔开。皮质祖细胞和多巴胺能祖细胞分别在促进皮质神经元和多巴胺能神经元分化的培养基中培养。然后移除屏障，形成一个包含皮质祖细胞和多巴胺能祖细胞的单室，两者之间有间隙隔开。然后在单一培养基中培养皮质祖细胞和多巴胺能祖细胞，促进神经元的进一步分化，并支持至少部分皮质神经元和多巴胺能神经元之间形成连接（如突触或类似突触的结构）。
• Compositions and methods for reprogramming non-neuronal cells into neuron-like cells
  申请人：Beihao Stem Cell and Regenerative Medicine Research Institutes Co., Ltd.

  公开号：US10857185B2

  公开（公告）日：2020-12-08

  Cocktails of chemical inducers of neuron-like properties (CINP) is provided, which includes cAMP agonists, neurogenic small molecules, glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, and BET family bromodomain inhibitors and optionally, a selective inhibitor of ROCK or p38 MAPK. These cocktails are used in a method of inducing neuron-like properties in partially or completely differentiated non-neuronal cells. The method includes contacting cells of a first type (non-neuronal) with the CINPs for a sufficient period of time to result in reprogramming the cell into cells of a second type having neuron-like characteristics (CiNs). Isolated chemically induced neurons (CiNs) can be used in a number of applications, including but not limited to cell therapy.

  本研究提供了神经元样特性化学诱导剂（CINP）鸡尾酒，其中包括 cAMP 激动剂、神经原小分子、糖原合酶激酶抑制剂、TGFβ 受体抑制剂、BET 家族溴域抑制剂以及 ROCK 或 p38 MAPK 的选择性抑制剂。这些鸡尾酒可用于在部分或完全分化的非神经元细胞中诱导神经元样特性的方法。该方法包括将第一种类型（非神经元）的细胞与 CINPs 接触足够长的时间，使细胞重编程为具有神经元样特性（CiNs）的第二种类型的细胞。分离的化学诱导神经元（CiNs）可用于多种应用，包括但不限于细胞疗法。
• A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS
  申请人：The Queen's University Of Belfast

  公开号：EP3630953A1

  公开（公告）日：2020-04-08