FR901533

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: FR901533
• 英文别名: Sodium;2-carboxy-1,6,14-trihydroxy-3-(2-hydroxypropyl)-7-methoxy-8,13-dioxo-5,6-dihydrobenzo[a]tetracen-9-olate；sodium;2-carboxy-1,6,14-trihydroxy-3-(2-hydroxypropyl)-7-methoxy-8,13-dioxo-5,6-dihydrobenzo[a]tetracen-9-olate
• 化学式: C₂₇H₂₁O₁₀*Na
• 分子量: 528.448
• InChiKey: OGDCHHBULODZAI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.87
• 重原子数：
  38
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  185
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  WS79089A 在 sodium hydroxide 作用下， 反应 0.5h， 以14 mg的产率得到FR901533
  参考文献：
  名称：

  WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

  摘要：

  WS79089A, B and C, which are novel endothelin converting enzyme (ECE) inhibitors have been isolated from the fermentation broth of Streptosporangium roseum No. 79089. These inhibitors were purified from an acetone extract of whole culture broth followed by Silicar CC-4 column chromatography and HPLC. WS79089A, B and C showed highly selective ECE inhibition activity with IC50 values of 0.73μM 0.14μM and 3.42μM, respectively. On the basis of spectroscopic and chemical evidence, the tentative structures of WS79089A, B and C have been proposed, they have benzo[a]naphtacen chromophores.

  DOI：

  10.7164/antibiotics.47.619

文献信息

• WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
  作者：YASUHISA TSURUMI、NOBUTAKA OHHATA、TOSHIRO IWAMOTO、NOBUHARU SHIGEMATSU、KAZUTOSHI SAKAMOTO、MOTOAKI NISHIKAWA、SUMIO KIYOTO、MASAKUNI OKUHARA

  DOI：10.7164/antibiotics.47.619

  日期：——

  WS79089A, B and C, which are novel endothelin converting enzyme (ECE) inhibitors have been isolated from the fermentation broth of Streptosporangium roseum No. 79089. These inhibitors were purified from an acetone extract of whole culture broth followed by Silicar CC-4 column chromatography and HPLC. WS79089A, B and C showed highly selective ECE inhibition activity with IC50 values of 0.73μM 0.14μM and 3.42μM, respectively. On the basis of spectroscopic and chemical evidence, the tentative structures of WS79089A, B and C have been proposed, they have benzo[a]naphtacen chromophores.